Journal of breast cancer · 2026
Solitary Fibrous Tumors of the Breast: Report of Two Cases and Systematic Review.
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Cheung Billy Ho Hung, Zhao Sha, Kwong Ava, Yeung Maximus
Аннотация
PURPOSE: Solitary fibrous tumors (SFTs) are rare mesenchymal neoplasms most commonly found in the pleura, but may also arise in other locations. Breast SFTs are extremely rare and infrequently reported. Descriptive data on the clinical, radiological, and pathological characteristics of breast SFTs are important for improving understanding of the disease, treatment strategies, and follow-up planning.
METHODS: The pathology databases of major surgical centers in Hong Kong, covering January 2020 to June 2023, were assessed to identify cases with a diagnostic code for SFT. A systematic literature search was conducted to identify all reported cases of breast SFTs. The search was performed using multiple scientific databases, including PubMed, Web of Science, Embase, and Scopus.
RESULTS: We report two cases of breast SFTs in Chinese female patients without a family history of breast cancer. Both patients presented with a palpable breast lump that appeared suspicious on ultrasonography (Breast Imaging-Reporting and Data System 4). Both patients underwent surgical excision of the lesions with negative margins. The diagnosis of SFT was established based on immunohistochemical findings in tumor samples obtained from surgical excision. No signs of recurrence were observed at follow-up. A literature review yielded 62 cases of breast SFT, including the two cases reported here. No clinically distinguishing features have been reported in the literature, other than that the majority of patients presented with a mass. SFTs were more commonly found in females (n = 47) than in males (n = 15), although the female-to-male ratio was lower than that observed in other breast cancers.
CONCLUSION: We describe two patients with breast SFTs, together with a comprehensive literature review, to contribute to the currently limited knowledge of this disease. A complete picture of the clinical, radiological, and pathological features of breast SFTs could help improve understanding of the condition and guide appropriate management.
METHODS: The pathology databases of major surgical centers in Hong Kong, covering January 2020 to June 2023, were assessed to identify cases with a diagnostic code for SFT. A systematic literature search was conducted to identify all reported cases of breast SFTs. The search was performed using multiple scientific databases, including PubMed, Web of Science, Embase, and Scopus.
RESULTS: We report two cases of breast SFTs in Chinese female patients without a family history of breast cancer. Both patients presented with a palpable breast lump that appeared suspicious on ultrasonography (Breast Imaging-Reporting and Data System 4). Both patients underwent surgical excision of the lesions with negative margins. The diagnosis of SFT was established based on immunohistochemical findings in tumor samples obtained from surgical excision. No signs of recurrence were observed at follow-up. A literature review yielded 62 cases of breast SFT, including the two cases reported here. No clinically distinguishing features have been reported in the literature, other than that the majority of patients presented with a mass. SFTs were more commonly found in females (n = 47) than in males (n = 15), although the female-to-male ratio was lower than that observed in other breast cancers.
CONCLUSION: We describe two patients with breast SFTs, together with a comprehensive literature review, to contribute to the currently limited knowledge of this disease. A complete picture of the clinical, radiological, and pathological features of breast SFTs could help improve understanding of the condition and guide appropriate management.