Journal of ethnopharmacology · 2026
Berberine sulphate protects against ethanol-induced gastric ulcer through antioxidant and anti-inflammatory mechanisms.
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Mahsud Kausar Ali, Arif Mehreen, Anwar Muhammad Syed, Ahmad Sajjad, Rehman Shafiq Ur, Niazi Zahid Rasul, Rehman Naeem Ur
Аннотация
AIM OF THE STUDY: The present study aimed to evaluate the gastroprotective effects of Berberine Sulphate against ethanol-induced gastric ulceration in BALB/c mice and to investigate the underlying antioxidant and anti-inflammatory mechanisms.
MATERIALS AND METHODS: Thirty-six male BALB/c mice were randomly allocated into six experimental groups. Berberine Sulphate (10, 20, and 40 mg/kg) and omeprazole (20 mg/kg) were orally administered for four consecutive days before induction of gastric ulcer using a single oral administration of 75% ethanol (0.2 mL/animal). Gastric pH, total acid secretion, ulcer index, histopathological alterations, antioxidant biomarkers (GSH and SOD), and inflammatory gene expression (TNF-α, IL-1β, IL-6, and NF-κB) were subsequently evaluated.
RESULTS: Results have shown that Berberine Sulphate has a significant gastroprotective effect in maintaining the anatomical vasculature of the stomach at the highest doses. The Berberine Sulphate groups demonstrated a dose-dependent increase in gastric pH with the highest Berberine Sulphate (6.87-6.95), reflecting its potent acid-suppressing effects. Berberine Sulphate also significantly restored antioxidant enzyme levels (GSH and SOD) and suppressed pro-inflammatory gene expression (TNF-α, IL-1β, IL-6, and NF-κB) in a dose-dependent manner. These pH, acid content, and ulcer score results correlate with the histopathological and gross anatomy findings, confirming the protective role of Berberine Sulphate in maintaining gastric mucosal integrity.
CONCLUSION: Our findings have suggested that Berberine Sulphate can be a potential candidate for the treatment of acute heavy ethanol-induced gastric ulcers. Although the findings provide comprehensive mechanistic evidence for the gastroprotective effects of Berberine Sulphate, further studies incorporating protein-level validation, additional oxidative stress biomarkers, and quantitative histopathological assessment are required.
MATERIALS AND METHODS: Thirty-six male BALB/c mice were randomly allocated into six experimental groups. Berberine Sulphate (10, 20, and 40 mg/kg) and omeprazole (20 mg/kg) were orally administered for four consecutive days before induction of gastric ulcer using a single oral administration of 75% ethanol (0.2 mL/animal). Gastric pH, total acid secretion, ulcer index, histopathological alterations, antioxidant biomarkers (GSH and SOD), and inflammatory gene expression (TNF-α, IL-1β, IL-6, and NF-κB) were subsequently evaluated.
RESULTS: Results have shown that Berberine Sulphate has a significant gastroprotective effect in maintaining the anatomical vasculature of the stomach at the highest doses. The Berberine Sulphate groups demonstrated a dose-dependent increase in gastric pH with the highest Berberine Sulphate (6.87-6.95), reflecting its potent acid-suppressing effects. Berberine Sulphate also significantly restored antioxidant enzyme levels (GSH and SOD) and suppressed pro-inflammatory gene expression (TNF-α, IL-1β, IL-6, and NF-κB) in a dose-dependent manner. These pH, acid content, and ulcer score results correlate with the histopathological and gross anatomy findings, confirming the protective role of Berberine Sulphate in maintaining gastric mucosal integrity.
CONCLUSION: Our findings have suggested that Berberine Sulphate can be a potential candidate for the treatment of acute heavy ethanol-induced gastric ulcers. Although the findings provide comprehensive mechanistic evidence for the gastroprotective effects of Berberine Sulphate, further studies incorporating protein-level validation, additional oxidative stress biomarkers, and quantitative histopathological assessment are required.