Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2010
Treatment of xanthelasma palpebrarum using a pulsed dye laser: a prospective clinical trial in 38 cases.
Клиническое исследованиеСравнительное исследованиеСтатьяНазвание и аннотация: Перевод в очереди
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Karsai Syrus, Czarnecka Agnieszka, Raulin Christian
Аннотация
BACKGROUND: Several studies have reported positive results of nonablative laser treatment of xanthelasma palpebrarum, but the published evidence is weak and inconclusive.
OBJECTIVE: To systematically evaluate the effect of pulsed dye laser (PDL) treatment of xanthelasmas.
MATERIALS AND METHODS: Twenty female Caucasian patients with 38 lesions (< or =1 mm above skin level) were enrolled. They received up to five treatment sessions with a PDL (wavelength, 585 nm; energy fluence, 7 J/cm(2); pulse duration, 0.5 ms; spot size, 10 mm; number of passes, 2) at 2- to 3-week intervals. Photographs were taken before each treatment session and 4 weeks after the last treatment. Two independent examiners categorized clearance into four groups (no clearance [<25% xanthelasma area(s) cleared], moderate [25-50%], good [51-75%], and excellent [>75%]). Patient satisfaction was assessed on a verbal rating scale.
RESULTS: Approximately two-thirds of the lesions showed clearance greater than 50%, and one-quarter had clearance greater than 75%. Interrater reliability was excellent (contingency coefficient >0.7 at all visits). Treatments were well tolerated and had no major side effects. Patient satisfaction was generally high.
CONCLUSION: PDL is a promising approach for treating xanthelasmas, especially when multiple sessions are performed.
OBJECTIVE: To systematically evaluate the effect of pulsed dye laser (PDL) treatment of xanthelasmas.
MATERIALS AND METHODS: Twenty female Caucasian patients with 38 lesions (< or =1 mm above skin level) were enrolled. They received up to five treatment sessions with a PDL (wavelength, 585 nm; energy fluence, 7 J/cm(2); pulse duration, 0.5 ms; spot size, 10 mm; number of passes, 2) at 2- to 3-week intervals. Photographs were taken before each treatment session and 4 weeks after the last treatment. Two independent examiners categorized clearance into four groups (no clearance [<25% xanthelasma area(s) cleared], moderate [25-50%], good [51-75%], and excellent [>75%]). Patient satisfaction was assessed on a verbal rating scale.
RESULTS: Approximately two-thirds of the lesions showed clearance greater than 50%, and one-quarter had clearance greater than 75%. Interrater reliability was excellent (contingency coefficient >0.7 at all visits). Treatments were well tolerated and had no major side effects. Patient satisfaction was generally high.
CONCLUSION: PDL is a promising approach for treating xanthelasmas, especially when multiple sessions are performed.