Acta cirurgica brasileira · 2026
Evaluation of polymeric films and streptokinase for prevention of postoperative intra-abdominal adhesion in rabbits.
СтатьяОценочное исследованиеНазвание и аннотация: Перевод в очереди
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Teixeira Luisa Gouvêa, Brito Helena Cristina Delgado, Teixeira Bruna Nunes, Barata Julielton de Souza, Adams Rozana da Rocha, Anai Letícia Abrahão, Martinato Fernanda, Matsui Andresa, Thiré Rossana Mara da Silva Moreira, Santana Áureo Evangelista
Аннотация
PURPOSE: To evaluate the effectiveness of polymer-based strategies for preventing intra-abdominal adhesions after small colon enterotomy and enterorrhaphy in a rabbit experimental model.
METHODS: Twenty-four female New Zealand White rabbits were randomly allocated into four groups (n = 6): film composed of a blend of sodium carboxymethylcellulose and polyvinyl alcohol (NaCMC-PVA); NaCMC-PVA-streptokinase (STP) film; intra-abdominal STP infusion; and no treatment. Hematological parameters were assessed preoperatively and at three and seven days postoperatively. Macroscopic evaluation of intra-abdominal adhesions and histopathological analysis of the enterorrhaphy site were performed on postoperative day 7. Results were compared within and between experimental groups.
RESULTS: Treated groups exhibited fewer hematological alterations compared with the control group. No statistically significant differences were observed among groups regarding adhesion severity or histopathological scores (p> 0.05). The NaCMC-PVA film showed the lowest absolute incidence of adhesions and did not impair intestinal remesothelialization.
CONCLUSION: Based on the biological findings from this study, the NaCMC-PVA film exhibited acceptable handling characteristics and biological compatibility. These findings suggest its potential as a mechanical barrier for preventing abdominal adhesion. However, further studies with larger sample sizes and longer follow-up periods are required to confirm its effectiveness.
METHODS: Twenty-four female New Zealand White rabbits were randomly allocated into four groups (n = 6): film composed of a blend of sodium carboxymethylcellulose and polyvinyl alcohol (NaCMC-PVA); NaCMC-PVA-streptokinase (STP) film; intra-abdominal STP infusion; and no treatment. Hematological parameters were assessed preoperatively and at three and seven days postoperatively. Macroscopic evaluation of intra-abdominal adhesions and histopathological analysis of the enterorrhaphy site were performed on postoperative day 7. Results were compared within and between experimental groups.
RESULTS: Treated groups exhibited fewer hematological alterations compared with the control group. No statistically significant differences were observed among groups regarding adhesion severity or histopathological scores (p> 0.05). The NaCMC-PVA film showed the lowest absolute incidence of adhesions and did not impair intestinal remesothelialization.
CONCLUSION: Based on the biological findings from this study, the NaCMC-PVA film exhibited acceptable handling characteristics and biological compatibility. These findings suggest its potential as a mechanical barrier for preventing abdominal adhesion. However, further studies with larger sample sizes and longer follow-up periods are required to confirm its effectiveness.