Journal of pharmacy & bioallied sciences · 2025
Assessing the Efficacy of Garlic Pearls Combined with Lycopene Capsules on Mouth Opening in Oral Submucous Fibrosis Patients.
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Jain Ishmita, Singh Vikas, Jain Ankita, Das Sukanya, Das Anirban, Shinde Christopher Vinay, Chowdhury Agamoni
Аннотация
BACKGROUND AND AIM: Oral submucous fibrosis (OSMF) is a debilitating premalignant condition affecting individuals across all age groups and both sexes. It is particularly prevalent in India and the South Asian subcontinent. Common clinical symptoms include reduced mouth opening and a burning sensation in the oral cavity.
MATERIALS AND METHODS: Study Design: Interventional Study Setting and Sample: This study was conducted at the outpatient department (OPD) of dental clinics and included patients clinically diagnosed with OSMF. A divider and scale were used to measure interincisal mouth opening at baseline and during follow-up intervals.
RESULTS: Intragroup comparisons revealed a statistically significant improvement in mouth opening over the 45-day treatment period. Improvement from Day 1 to Day 15 was significant (P = 0.002), with continued progress from Day 15 to Day 30 (P = 0.003), and from Day 30 to Day 45 (P = 0.011). These findings suggest that the combination of lycopene and garlic was effective in enhancing mouth opening in OSMF patients over time.
CONCLUSION: The study demonstrated a significant improvement in mouth opening among OSMF patients treated with a 45-day regimen of lycopene capsules and garlic pearls. These findings highlight the therapeutic potential of this antioxidant-based combination in the management of OSMF.
MATERIALS AND METHODS: Study Design: Interventional Study Setting and Sample: This study was conducted at the outpatient department (OPD) of dental clinics and included patients clinically diagnosed with OSMF. A divider and scale were used to measure interincisal mouth opening at baseline and during follow-up intervals.
RESULTS: Intragroup comparisons revealed a statistically significant improvement in mouth opening over the 45-day treatment period. Improvement from Day 1 to Day 15 was significant (P = 0.002), with continued progress from Day 15 to Day 30 (P = 0.003), and from Day 30 to Day 45 (P = 0.011). These findings suggest that the combination of lycopene and garlic was effective in enhancing mouth opening in OSMF patients over time.
CONCLUSION: The study demonstrated a significant improvement in mouth opening among OSMF patients treated with a 45-day regimen of lycopene capsules and garlic pearls. These findings highlight the therapeutic potential of this antioxidant-based combination in the management of OSMF.