Stroke (Hoboken, N.J.) · 2023
Safety of Intravenous Cangrelor Versus Dual Oral Antiplatelet Loading Therapy in Endovascular Treatment of Tandem Lesions: An Observational Cohort Study.
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Rodriguez-Calienes Aaron, Oliver Marion, Hassan Ameer E, Vivanco-Suarez Juan, Divani Afshin A, Ribo Marc, Petersen Nils, Abraham Michael, Fifi Johanna, Guerrero Waldo R, Malik Amer M, Siegler James E, Nguyen Thanh, Sheth Sunil, Yoo Albert, Linares Guillermo, Janjua Nazli, Quispe-Orozco Darko, Galecio-Castillo Milagros, Alhajala Hisham, Malaga Marco, Farooqui Mudassir, Jovin Tudor, Jumaa Mouhammad, Ortega-Gutierrez Santiago
Аннотация
BACKGROUND: Procedural intravenous cangrelor has been proposed as an effective platelet inhibition strategy for stenting in acute ischemic stroke. We aimed to compare the safety profile of low-dose intravenous cangrelor versus dual oral antiplatelet therapy (DAPT) loading in patients with acute cervical tandem lesions.
METHODS: We retrospectively identified cases from an international multicenter cohort who underwent intraprocedural administration of intravenous cangrelor (15 μg/kg followed by an infusion of 2 μg/kg per min) or DAPT loading during acute tandem lesions intervention. Safety outcomes included rates of symptomatic intracranial hemorrhage, parenchymal hematoma type 2, petechial hemorrhage, and in-stent thrombosis. Inverse probability of treatment weighting matching was used to reduce confounding.
RESULTS: From 691 patients, we included 195 patients, 30 of whom received intravenous cangrelor and 165 DAPT. The DAPT regimens were aspirin+clopidogrel (93.3%) or aspirin+ticagrelor (6.6%). After inverse probability of treatment weighting, the patients treated with cangrelor were not at greater odds of symptomatic intracranial hemorrhage (odds ratio [OR], 1.30 [95% CI, 0.09-17.3]; P=0.837), symptomatic intracranial hemorrhage-parenchymal hematoma type 2 (OR, 0.54 [95% CI, 0.05-4.98]; P=0.589), or petechial hemorrhage (OR, 1.11 [95% CI, 0.38-3.28]; P=0.836). Similarly, the rate of in-stent thrombosis was not significantly different between the 2 groups (1.8% versus 0%; P=0.911).
CONCLUSION: Cangrelor at the half dose of the myocardial infarction protocol showed a similar safety profile compared with the commonly used DAPT loading protocols in patients with acute tandem lesions. Further studies with larger samples are warranted to elucidate the safety of antiplatelet therapy in tandem lesions.
METHODS: We retrospectively identified cases from an international multicenter cohort who underwent intraprocedural administration of intravenous cangrelor (15 μg/kg followed by an infusion of 2 μg/kg per min) or DAPT loading during acute tandem lesions intervention. Safety outcomes included rates of symptomatic intracranial hemorrhage, parenchymal hematoma type 2, petechial hemorrhage, and in-stent thrombosis. Inverse probability of treatment weighting matching was used to reduce confounding.
RESULTS: From 691 patients, we included 195 patients, 30 of whom received intravenous cangrelor and 165 DAPT. The DAPT regimens were aspirin+clopidogrel (93.3%) or aspirin+ticagrelor (6.6%). After inverse probability of treatment weighting, the patients treated with cangrelor were not at greater odds of symptomatic intracranial hemorrhage (odds ratio [OR], 1.30 [95% CI, 0.09-17.3]; P=0.837), symptomatic intracranial hemorrhage-parenchymal hematoma type 2 (OR, 0.54 [95% CI, 0.05-4.98]; P=0.589), or petechial hemorrhage (OR, 1.11 [95% CI, 0.38-3.28]; P=0.836). Similarly, the rate of in-stent thrombosis was not significantly different between the 2 groups (1.8% versus 0%; P=0.911).
CONCLUSION: Cangrelor at the half dose of the myocardial infarction protocol showed a similar safety profile compared with the commonly used DAPT loading protocols in patients with acute tandem lesions. Further studies with larger samples are warranted to elucidate the safety of antiplatelet therapy in tandem lesions.