Lack of association between rs1049353 polymorphism of the CNR1 gene and suicide attempt frequency in Polish population.

UNLABELLED: Suicidal behaviour is a major public health problem in Poland. There is compelling evidence that genetic factors contribute to the risk for suicidal behavior. Studies suggest a link between single nucleotide polymorphism (SNP) rs1049353 (1359 G/A; Thr453Thr) of cannabinoid receptor 1 gene (CNR1) and mental disorders, including suicide behaviour.

AIM: The purpose of the study was to determine whether 1359 G/ A polymorphism of CNR1 is more frequent in people attempting suicide than in the general population.

MATERIALS AND

METHODS

A sample of 76 genetically unrelated participants were enrolled into the study: 48 patients after a suicide attempt and the control group - 28 individuals without a history of suicide attempts. The genotyping of 1359 G/A polymorphism of CNR1 gene was performed with the application of Restriction Fragment Length Polymorphism (RFLP) analysis.

RESULTS

None of the 1359 G/A polymorphisms of CNR1 gene seem to occur more frequently among individuals who attempted suicide.

CONCLUSIONS

Further research with larger samples with different racial and geographic origins are needed in the future.