The Journal of clinical endocrinology and metabolism · 2025
Deciphering the Presentation and Etiologies of Hypophysitis Highlights the Need for Repeated Systematical Investigation.
СтатьяНаблюдательное исследованиеНазвание и аннотация: Перевод в очереди
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Miquel Lea, Testud Benoit, Albarel Frederique, Sahakian Nicolas, Cuny Thomas, Graillon Thomas, Brue Thierry, Dufour Henri, Schleinitz Nicolas, Kaplanski Gilles, Ebbo Mikael, Castinetti Frederic
Аннотация
CONTEXT: Hypophysitis is defined as an inflammation of the pituitary gland and/or infundibulum.
OBJECTIVE: Our aim was to characterize the initial course and evolution of patients with hypophysitis according to the different etiologies.
METHODS: Retrospective observational study conducted in a university referral hospital center. Patients over 15 years of age were included if they had a diagnosis of hypophysitis between January 2014 and October 2023, with the exclusion of hypophysitis secondary to immune checkpoint inhibitors.
RESULTS: Sixty-one patients (64% women; median age, 34 years) were included. Polyuria-polydipsia, headache, and asthenia were present in 64%, 48%, and 44% of cases respectively. At diagnosis, at least 1 anterior pituitary deficiency was present in 91.5% of cases and vasopressin deficiency in 56%. Magnetic resonance imaging was abnormal in 97% of cases. Secondary hypophysitis was found in 46% of cases (n = 28), including sarcoidosis in 28% (n = 17) and L (Langerhans) group histiocytoses in 13.1% (n = 8). Among patients with secondary hypophysitis, pituitary deficiency preceded systemic manifestations in 23% and occurred concomitantly in 23% of cases. Patients were treated in 36% of cases (glucocorticoids, surgery), without improvement of pituitary hormone deficits.
CONCLUSION: A systemic etiology of hypophysitis was found in almost half of the patients. Pituitary disorders preceded the systemic disease in a quarter of the cases. This emphasizes the importance of a systematic repeated workup looking for a secondary etiology of hypophysitis in these patients.
OBJECTIVE: Our aim was to characterize the initial course and evolution of patients with hypophysitis according to the different etiologies.
METHODS: Retrospective observational study conducted in a university referral hospital center. Patients over 15 years of age were included if they had a diagnosis of hypophysitis between January 2014 and October 2023, with the exclusion of hypophysitis secondary to immune checkpoint inhibitors.
RESULTS: Sixty-one patients (64% women; median age, 34 years) were included. Polyuria-polydipsia, headache, and asthenia were present in 64%, 48%, and 44% of cases respectively. At diagnosis, at least 1 anterior pituitary deficiency was present in 91.5% of cases and vasopressin deficiency in 56%. Magnetic resonance imaging was abnormal in 97% of cases. Secondary hypophysitis was found in 46% of cases (n = 28), including sarcoidosis in 28% (n = 17) and L (Langerhans) group histiocytoses in 13.1% (n = 8). Among patients with secondary hypophysitis, pituitary deficiency preceded systemic manifestations in 23% and occurred concomitantly in 23% of cases. Patients were treated in 36% of cases (glucocorticoids, surgery), without improvement of pituitary hormone deficits.
CONCLUSION: A systemic etiology of hypophysitis was found in almost half of the patients. Pituitary disorders preceded the systemic disease in a quarter of the cases. This emphasizes the importance of a systematic repeated workup looking for a secondary etiology of hypophysitis in these patients.