Granular Cell Tumor of the Dorsal Tongue in a 58-Year-Old Woman: A Case Report.

Granular cell tumor (GCT) is a rare, typically benign neoplasm of Schwann cell origin, most commonly affecting the oral cavity and particularly the tongue. We report a case of a 58-year-old woman who presented with a painless, slow-growing submucosal nodule on the dorsal surface of the tongue. Clinical examination revealed a firm, well-circumscribed lesion, which was excised under local anesthesia. Histopathological analysis demonstrated large polygonal cells with granular eosinophilic cytoplasm and overlying pseudoepitheliomatous hyperplasia (PEH), while immunohistochemistry confirmed strong positivity for S-100, SOX10, and CD68, consistent with a benign GCT. No adverse histological features or malignant transformation were observed. The lesion was excised completely with narrow but clear margins, and the patient remains recurrence-free at six months of follow-up. This case highlights the importance of recognizing the characteristic histopathological and immunohistochemical features of GCT, especially in the presence of PEH, which may mimic squamous cell carcinoma. Complete excision with vigilant follow-up remains the treatment of choice, with an excellent prognosis in most cases.