Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery · 2025
IL-11 as a potential diagnostic and prognostic biomarker in oral submucous fibrosis-related oral squamous cell carcinoma: A single-center exploratory study.
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Liu Yuxin, Quan Hongzhi
Аннотация
BACKGROUND: Oral submucous fibrosis (OSF) has a high propensity for malignant transformation, and oral squamous cell carcinoma (OSCC) associated with OSF exhibits different clinical and pathological features compared to non-OSF-related OSCC. It aimed to investigate the expression characteristics of peripheral blood interleukins (ILs) in patients with OSF-related OSCC and their relationship with clinical and pathological features.
METHODS: A total of 219 OSCC patients were included and divided into OSF group (OG, n = 115) and non-OSF group (nOG, n = 104). Additionally, 119 healthy volunteers were recruited through community health screening as the healthy control group (HCG). Clinical and pathological data were collected, and ILs in peripheral blood were measured. The levels of IL-11 in peripheral blood of OSF-related OSCC patients with different pathological features were compared.
RESULTS: Compared to the nOG and HCG, the OG exhibited a lower proportion of individuals aged ≥65 years, a higher proportion of males, and significantly elevated levels of IL-2 and IL-11. Additionally, compared to the nOG, the OG demonstrated lower recurrence and mortality rates, as well as a higher proportion of oral tumors and well-differentiated pathological features (P < 0.05). The area under the curve (AUC) for diagnosing OSF-related OSCC based on the levels of IL-2, IL-4, IL-10, and IL-11 in peripheral blood were 0.671, 0.593, 0.570, and 0.725, respectively. IL-11 levels were correlated with the degree of differentiation, lymph node metastasis (LNM), clinical staging, prognosis, and 5-year survival status in patients with OSF-related OSCC (P < 0.05).
CONCLUSION: Elevated IL-11 in peripheral blood of patients with OSF-related OSCC are closely associated with clinical and pathological features.
METHODS: A total of 219 OSCC patients were included and divided into OSF group (OG, n = 115) and non-OSF group (nOG, n = 104). Additionally, 119 healthy volunteers were recruited through community health screening as the healthy control group (HCG). Clinical and pathological data were collected, and ILs in peripheral blood were measured. The levels of IL-11 in peripheral blood of OSF-related OSCC patients with different pathological features were compared.
RESULTS: Compared to the nOG and HCG, the OG exhibited a lower proportion of individuals aged ≥65 years, a higher proportion of males, and significantly elevated levels of IL-2 and IL-11. Additionally, compared to the nOG, the OG demonstrated lower recurrence and mortality rates, as well as a higher proportion of oral tumors and well-differentiated pathological features (P < 0.05). The area under the curve (AUC) for diagnosing OSF-related OSCC based on the levels of IL-2, IL-4, IL-10, and IL-11 in peripheral blood were 0.671, 0.593, 0.570, and 0.725, respectively. IL-11 levels were correlated with the degree of differentiation, lymph node metastasis (LNM), clinical staging, prognosis, and 5-year survival status in patients with OSF-related OSCC (P < 0.05).
CONCLUSION: Elevated IL-11 in peripheral blood of patients with OSF-related OSCC are closely associated with clinical and pathological features.