Nature genetics · 2021

The first wave of the COVID-19 epidemic in Spain was associated with early introductions and fast spread of a dominating genetic variant.

СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди

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López Mariana G, Chiner-Oms Álvaro, García de Viedma Darío, Ruiz-Rodriguez Paula, Bracho Maria Alma, Cancino-Muñoz Irving, D'Auria Giuseppe, de Marco Griselda, García-González Neris, Goig Galo Adrian, Gómez-Navarro Inmaculada, Jiménez-Serrano Santiago, Martinez-Priego Llúcia, Ruiz-Hueso Paula, Ruiz-Roldán Lidia, Torres-Puente Manuela, Alberola Juan, Albert Eliseo, Aranzamendi Zaldumbide Maitane, Bea-Escudero María Pilar, Boga Jose Antonio, Bordoy Antoni E, Canut-Blasco Andrés, Carvajal Ana, Cilla Eguiluz Gustavo, Cordón Rodríguez Maria Luz, Costa-Alcalde José J, de Toro María, de Toro Peinado Inmaculada, Del Pozo Jose Luis, Duchêne Sebastián, Fernández-Pinero Jovita, Fuster Escrivá Begoña, Gimeno Cardona Concepción, González Galán Verónica, Gonzalo Jiménez Nieves, Hernáez Crespo Silvia, Herranz Marta, Lepe José Antonio, López-Causapé Carla, López-Hontangas José Luis, Martín Vicente, Martró Elisa, Milagro Beamonte Ana, Montes Ros Milagrosa, Moreno-Muñoz Rosario, Navarro David, Navarro-Marí José María, Not Anna, Oliver Antonio, Palop-Borrás Begoña, Parra Grande Mónica, Pedrosa-Corral Irene, Pérez González Maria Carmen, Pérez-Lago Laura, Pérez-Ruiz Mercedes, Piñeiro Vázquez Luis, Rabella Nuria, Rezusta Antonio, Robles Fonseca Lorena, Rodríguez-Villodres Ángel, Sanbonmatsu-Gámez Sara, Sicilia Jon, Soriano Alex, Tirado Balaguer María Dolores, Torres Ignacio, Tristancho Alexander, Marimón José María, SeqCOVID-Spain consortium, Coscolla Mireia, González-Candelas Fernando, Comas Iñaki

Аннотация

The coronavirus disease 2019 (COVID-19) pandemic has affected the world radically since 2020. Spain was one of the European countries with the highest incidence during the first wave. As a part of a consortium to monitor and study the evolution of the epidemic, we sequenced 2,170 samples, diagnosed mostly before lockdown measures. Here, we identified at least 500 introductions from multiple international sources and documented the early rise of two dominant Spanish epidemic clades (SECs), probably amplified by superspreading events. Both SECs were related closely to the initial Asian variants of SARS-CoV-2 and spread widely across Spain. We inferred a substantial reduction in the effective reproductive number of both SECs due to public-health interventions (Re < 1), also reflected in the replacement of SECs by a new variant over the summer of 2020. In summary, we reveal a notable difference in the initial genetic makeup of SARS-CoV-2 in Spain compared with other European countries and show evidence to support the effectiveness of lockdown measures in controlling virus spread, even for the most successful genetic variants.

Предметные рубрики MeSH

COVID-19 Communicable Disease Control Humans Incidence Models, Statistical Phylogeny Physical Distancing Quarantine SARS-CoV-2 Severity of Illness Index Spain

The first wave of the COVID-19 epidemic in Spain was associated with early introductions and fast spread of a dominating genetic variant.

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Аннотация

Предметные рубрики MeSH