BMC neurology · 2025
Case report: Coexistence of optic neuritis and primary anti-PLA2R-positive membranous nephropathy.
СтатьяКлинический случайНазвание и аннотация: Перевод в очереди
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Wang Xi, Zeng Yuping, Zhao Yuliang, Li Boyi, Yang Jing
Аннотация
BACKGROUND: Optic neuritis (ON) is an inflammatory optic neuropathy characterized by acute vision loss. Primary anti-PLA2R-positive membranous nephropathy, an autoimmune disease, has been reported to be related to neurological diseases. However, the co-occurrence of ON and primary membranous nephropathy (PMN) has not been reported.
CASE PRESENTATION: A 57-year-old male presented with acute bilateral vision loss. Laboratory tests indicated proteinuria, hypoalbuminemia, hyperlipidemia, and a significantly increased level of anti-phospholipase A2 receptor antibody (PLA2RAb). Orbital MRI revealed inflammatory changes in the posterior segments of both optic nerves. Following treatments with corticosteroids and immunosuppressants, there was a significant improvement in the patient's vision and proteinuria.
CONCLUSION: This case suggests that early identification and intervention for multisystem autoimmune damages are crucial for improving patient prognosis.
CASE PRESENTATION: A 57-year-old male presented with acute bilateral vision loss. Laboratory tests indicated proteinuria, hypoalbuminemia, hyperlipidemia, and a significantly increased level of anti-phospholipase A2 receptor antibody (PLA2RAb). Orbital MRI revealed inflammatory changes in the posterior segments of both optic nerves. Following treatments with corticosteroids and immunosuppressants, there was a significant improvement in the patient's vision and proteinuria.
CONCLUSION: This case suggests that early identification and intervention for multisystem autoimmune damages are crucial for improving patient prognosis.