The correlation between impaired thyroid hormone sensitivity and 10-year atherosclerotic cardiovascular disease (ASCVD) risk score in patients with type 2 diabetes mellitus.

BackgroundAtherosclerotic cardiovascular disease (ASCVD) is one of the common complications in patients with type 2 diabetes mellitus (T2DM). Thyroid hormones affect cardiovascular function through multiple pathways.PurposeTo explore the relationships between impaired thyroid hormone sensitivity and the 10-year risk of ASCVD in euthyroid patients with T2DM.Methods899 patients with T2DM were divided into three groups according to the different ASCVD risk levels, the difference of thyroid hormone sensitivity indices [Parametric Thyroid Feedback Quantile-based Index (PTFQI), Thyroid Feedback Quantile-based Index (TFQI), Thyroid Stimulating Hormone Index (TSHI), Serum-Free triiodothyronine to Free thyroxine (FT3/FT4) ratio, and Thyrotropin Thyroxine Resistance Index (TT4RI)] between three groups were compared.ResultsAs the 10-year ASCVD risk grade increased, TT4RI level showed a gradually rising trend, while FT3/FT4 ratio exhibited a decreasing trend (P < 0.05). PTFQI, TFQI, TSHI, and TT4RI were positively, and FT3/FT4 was negatively correlated with ASCVD risk (all P < 0.05). Thyroid hormone sensitivity indicators had a linear dose-response relationships with ASCVD risk. As the levels of PTFQI, TFQI, TSHI, and TT4RI increase and the level of FT3/FT4 decreases, the ASCVD risk showed an upward trend.ConclusionTo patients with T2DM, impaired thyroid hormone sensitivity is associated with ASCVD risk.