Expert opinion on biological therapy · 2025
Treatment progress of inherited epidermolysis bullosa.
СтатьяОбзорНазвание и аннотация: Перевод в очереди
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Wang Wen-Ming, Feng Hao, Jia Qian-Nan, Jin Hong-Zhong
Аннотация
INTRODUCTION: Inherited epidermolysis bullosa (EB) is a family of rare-inherited dermatoses that result in mucocutaneous fragility and blister formation inducible by minor trauma. Clinically, EB mainly presents as increased skin fragility with trauma-induced blisters and erosions, combined with extracutaneous manifestations and their complications in other epithelialized organs. No cure for inherited EB is currently available. Treatment of inherited EB is mainly supportive, aiming to reduce patients' pain and itching.
AREAS COVERED: Some advances in the treatment of inherited epidermolysis bullosa have recently been achieved, including topical drug treatment, systemic drug treatment, gene-based therapy, and cell-based therapy. This review focuses on the treatment progress of inherited epidermolysis bullosa. PubMed was searched up to February 2025 to identify relevant studies on inherited EB.
EXPERT OPINION: Emerging advances of therapies in gene-based therapy and cell-based therapy can partially address the symptoms of EB and provide hope for the patients.
AREAS COVERED: Some advances in the treatment of inherited epidermolysis bullosa have recently been achieved, including topical drug treatment, systemic drug treatment, gene-based therapy, and cell-based therapy. This review focuses on the treatment progress of inherited epidermolysis bullosa. PubMed was searched up to February 2025 to identify relevant studies on inherited EB.
EXPERT OPINION: Emerging advances of therapies in gene-based therapy and cell-based therapy can partially address the symptoms of EB and provide hope for the patients.