Brain and behavior · 2025
Opposing Influences of Optic Neuritis and Transverse Myelitis on the Future Location of Relapses in MOG Antibody-Associated Disease.
СтатьяНазвание и аннотация: Перевод в очереди
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San Martin Daniel Lordelo, Portela Filho Marcos Baruch, Rocchi Chiara, Hamid Shahd, Huda Saif
Аннотация
BACKGROUND: Studies in MS and NMOSD have shown that relapses can frequently occur in the same location as the first attack. Factors associated with this outcome in MOGAD are unclear.
OBJECTIVE: The objective of this study was to investigate the likelihood of a relapse occurring at the same site in MOGAD.
METHODS: This was a UK national cohort study. MOGAD patients with a minimum of one relapse and one year of follow-up were included. To identify factors associated with relapse location, logistic regression was performed.
RESULTS: An increased risk of a relapse in the same location was observed when the first attack was optic neuritis-for the second attack (OR 12.9, 95% CI 3.31-50.55, p = .001) and all subsequent attacks (OR 5.39 95% CI 1.61-18.03, p = .006). Conversely, a reduced risk of relapse in the same location was associated with transverse myelitis-for the second attack (OR 0.25, 95% CI 0.07-0.82, p = .022) and all subsequent attacks (OR 0.25 95% CI 0.06-0.96, p = .045).
CONCLUSION: In relapsing MOGAD, patients with optic neuritis are at high risk of a new attack in the same location, while those with transverse myelitis are at low risk.
OBJECTIVE: The objective of this study was to investigate the likelihood of a relapse occurring at the same site in MOGAD.
METHODS: This was a UK national cohort study. MOGAD patients with a minimum of one relapse and one year of follow-up were included. To identify factors associated with relapse location, logistic regression was performed.
RESULTS: An increased risk of a relapse in the same location was observed when the first attack was optic neuritis-for the second attack (OR 12.9, 95% CI 3.31-50.55, p = .001) and all subsequent attacks (OR 5.39 95% CI 1.61-18.03, p = .006). Conversely, a reduced risk of relapse in the same location was associated with transverse myelitis-for the second attack (OR 0.25, 95% CI 0.07-0.82, p = .022) and all subsequent attacks (OR 0.25 95% CI 0.06-0.96, p = .045).
CONCLUSION: In relapsing MOGAD, patients with optic neuritis are at high risk of a new attack in the same location, while those with transverse myelitis are at low risk.