Comparative study of the clinicopathologic characteristics and immunohistochemical expression of recurrent and nonrecurrent glandular odontogenic cysts: a retrospective longitudinal cohort multicenter study.

OBJECTIVE

The objective of this study was to analyze the clinicopathological profile of recurrent and non-recurrent glandular odontogenic cyst (GOC) through a longitudinal cohort multicenter study.

STUDY

DESIGN

This multicenter longitudinal cohort study investigates factors associated with GOC recurrence. Included in the study were patients with histologically confirmed GOC (per Fowler's criteria), who experienced recurrence at least 1-year post-treatment. Controls were GOCs with a minimum of 5 years of recurrence-free follow-up. Histologic features, treatment rendered, and immunohistochemical staining results for CK13, CK19, and Ki-67 were documented.

RESULTS

Eleven recurrent cases (6 men and 5 women; mean age = 56.09 years) were analyzed. The anterior mandible was the most frequently affected site (45.5%), followed by the posterior and anterior maxilla (27.1% each). The average follow-up time was 36.1 months. Recurrence was significantly associated with multiple compartments and the absence of apocrine snouting (P = .013, P = .034, respectively). The majority of the primary GOCs that later recurred were treated with enucleation (73%).

CONCLUSIONS

Multiple compartments and lack of apocrine snouting may be a histological predictor of recurrence. All recurrent cases were treated with enucleation and/or curettage, highlighting treatment approach as a key factor. (Oral Surg Oral Med Oral Pathol Oral Radiol YEAR;VOL:page range).