European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology · 2025
Incidence and risk factors of cerebral hyper-perfusion syndrome like symptoms after resection of carotid body tumours.
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Gao Jianfeng, Gu Guangchao, Zeng Rong, Chen Yuexin, Ye Wei, Zheng Yuehong
Аннотация
INTRODUCTION: Cerebral hyper-perfusion syndrome (CHS) is a rare but severe complication after surgery of carotid artery related disease (with a varied incidence range of 0-25.7 %), while its association with carotid body tumour (CBT) surgery is unknown. This study aimed to investigate the incidence and risk factors of CHS-like symptoms after resection of CBTs.
METHODS: This retrospective study included 152 CBT patients (165 operated tumours) who received surgery at Peking Union Medical College Hospital from March 2013 to December 2021 and had fully-available clinical records. Surgeries were performed by the several operation teams (around 4-5 teams during the study period) from the department of vascular surgery, of which the team leaders were all senior vascular surgeons who had full experience on CBT surgery. CHS-like symptom was determined based on clinical manifestation and its risk factors were identified by univariate and multivariate regression analyses.
RESULTS: The mean age of this cohort was 44.2 ± 10.9 years and female patients represented 67.1 % (102/152). There were 13 (13/152, 10.5 %) cases receiving bilateral CBT resections, generating a total of 165 operated tumours. The median maximum diameter of the tumours was 3.5 cm (IQR: 2.5-4.8 cm), with 37 (22.4 %), 40 (24.2 %) and 88 (53.3 %) lesions being classified as Shamblin I, II and III, respectively. All CBTs were completely resected under general anaesthesia, with 51 patients undergoing balloon occlusion tests (51/152, 33.6 %) preoperatively and no preoperative embolization was performed. During surgery, 34 cases (34/165, 20.6 %) underwent intervention for internal carotid artery (ICA) and 43 cases (43/165, 26.1 %) underwent external carotid artery ligation. Among the 165 operations, 43 cases developed CHS-like symptoms after surgery (26.1 %, 43/165), of which 26 cases received dehydrant therapy due to severe symptoms (60.5 %, 26/43) and most cases developed symptoms within 48 h after surgery (90.7 %,39/43). Univariate analysis revealed that occurrence of CHS-like symptoms is significantly related with elevated post-operation immediate heart rate (HR) (P = 0.006), post-operation day 1 morning HR (P = 0.004), ICA intervention (P = 0.002) and postoperative new-onset hypertension (P = 0.02). Furthermore, ICA intervention (P = 0.008) and new-onset hypertension (P = 0.017) remained the independent risk factors for development of CHS-like symptoms in multivariate regression analysis.
CONCLUSION: CBT excision is related to a significant incidence of postoperative CHS-like symptoms, of which intraoperative ICA intervention and post-operative new-onset hypertension are the independent risk factors, thus more attention and closer monitoring should be given on such patients so as to prevent life-threatening CHS-related cerebral complications.
METHODS: This retrospective study included 152 CBT patients (165 operated tumours) who received surgery at Peking Union Medical College Hospital from March 2013 to December 2021 and had fully-available clinical records. Surgeries were performed by the several operation teams (around 4-5 teams during the study period) from the department of vascular surgery, of which the team leaders were all senior vascular surgeons who had full experience on CBT surgery. CHS-like symptom was determined based on clinical manifestation and its risk factors were identified by univariate and multivariate regression analyses.
RESULTS: The mean age of this cohort was 44.2 ± 10.9 years and female patients represented 67.1 % (102/152). There were 13 (13/152, 10.5 %) cases receiving bilateral CBT resections, generating a total of 165 operated tumours. The median maximum diameter of the tumours was 3.5 cm (IQR: 2.5-4.8 cm), with 37 (22.4 %), 40 (24.2 %) and 88 (53.3 %) lesions being classified as Shamblin I, II and III, respectively. All CBTs were completely resected under general anaesthesia, with 51 patients undergoing balloon occlusion tests (51/152, 33.6 %) preoperatively and no preoperative embolization was performed. During surgery, 34 cases (34/165, 20.6 %) underwent intervention for internal carotid artery (ICA) and 43 cases (43/165, 26.1 %) underwent external carotid artery ligation. Among the 165 operations, 43 cases developed CHS-like symptoms after surgery (26.1 %, 43/165), of which 26 cases received dehydrant therapy due to severe symptoms (60.5 %, 26/43) and most cases developed symptoms within 48 h after surgery (90.7 %,39/43). Univariate analysis revealed that occurrence of CHS-like symptoms is significantly related with elevated post-operation immediate heart rate (HR) (P = 0.006), post-operation day 1 morning HR (P = 0.004), ICA intervention (P = 0.002) and postoperative new-onset hypertension (P = 0.02). Furthermore, ICA intervention (P = 0.008) and new-onset hypertension (P = 0.017) remained the independent risk factors for development of CHS-like symptoms in multivariate regression analysis.
CONCLUSION: CBT excision is related to a significant incidence of postoperative CHS-like symptoms, of which intraoperative ICA intervention and post-operative new-onset hypertension are the independent risk factors, thus more attention and closer monitoring should be given on such patients so as to prevent life-threatening CHS-related cerebral complications.