Journal of the neurological sciences · 2025
A subgroup of multiple system atrophy with rapid decline in vital capacity.
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Okubo So, Orimo Kenta, Matsukawa Takashi, Hamada Masashi, Satake Wataru, Mitsui Jun, Toda Tatsushi
Аннотация
INTRODUCTION: Patients with neurodegenerative disorders resulting in progressive dysphagia often require gastrostomy. Pulmonary function tests (PFTs) are crucial in presurgical evaluation; however, reports on pulmonary function in multiple system atrophy (MSA) and progressive supranuclear palsy (PSP) are limited.
MATERIALS AND METHODS: This single-center, retrospective study analyzed the PFT records from patients with MSA and PSP admitted between January 2012 and October 2023.
RESULTS: Data from 104 PFTs in 70 patients with MSA (21 MSA-P, 49 MSA-C) and 29 PFTs in 22 patients with PSP, showed a weak correlation between the percentage of measured vital capacity to the predicted vital capacity (%VC) and disease duration (MSA: -0.34 and PSP: -0.19). The variation in %VC decline was greater in MSA than in PSP, with a rapid progression (%VC < 65 % within 5 years of disease duration) in seven patients with MSA (6 MSA-P and 1 MSA-C).
CONCLUSION: A decline in %VC with disease duration was observed in both MSA and PSP, with greater variation observed in MSA. Notably, a rapid decline in %VC was predominantly observed in patients with MSA-P during the early courses.
MATERIALS AND METHODS: This single-center, retrospective study analyzed the PFT records from patients with MSA and PSP admitted between January 2012 and October 2023.
RESULTS: Data from 104 PFTs in 70 patients with MSA (21 MSA-P, 49 MSA-C) and 29 PFTs in 22 patients with PSP, showed a weak correlation between the percentage of measured vital capacity to the predicted vital capacity (%VC) and disease duration (MSA: -0.34 and PSP: -0.19). The variation in %VC decline was greater in MSA than in PSP, with a rapid progression (%VC < 65 % within 5 years of disease duration) in seven patients with MSA (6 MSA-P and 1 MSA-C).
CONCLUSION: A decline in %VC with disease duration was observed in both MSA and PSP, with greater variation observed in MSA. Notably, a rapid decline in %VC was predominantly observed in patients with MSA-P during the early courses.