International ophthalmology · 2026
Two current biomarkers in major depressive disorder: peripapillary and subfoveal choroidal vascular indexes.
СтатьяСравнительное исследованиеНазвание и аннотация: Перевод в очереди
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Icoz Mehmet, Yalvac Tugba, Erkan Eyup
Аннотация
PURPOSE: To investigate the peripapillary (p) and subfoveal (sf) choroidal vascular index (CVI) parameters in newly diagnosed major depressive disorder (MDD).
METHODS: This prospective comparative study was conducted on 50 patients with newly diagnosed MDD and 50 age- and sex-matched healthy participants. All participants underwent an ophthalmological examination, and their demographic characteristics were recorded. Choroidal images obtained from the HD-line optical coherence tomography sections of both groups were analyzed in both the foveal and peripapillary regions.Choroidal thickness measurements were obtained, and choroidal vascular parameters were determined using a specialized free software program.These parameters included the luminal choroidal area (LCA), stromal choroidal area (SCA), and total choroidal area (TCA).The ratio of LCA to TCA was defined as CVI.
RESULTS: No statistically significant differences were found between the groups concerning choroidal thickness, optic disc head measurements, or peripapillary retinal nerve fiber layer thickness (p > 0.05 for all).In the MDD group, the sfLCA was 0.11 ± 0.04 mm2 and the pLCA was 0.12 ± 0.03 mm2, whereas in the control group, these measurements were 0.16 ± 0.05 mm2 and 0.16 ± 0.02 mm2, respectively (p = 0.003 and p = 0.005,respectively).The sfCVI values were 0.61 ± 0.03 in the MDD group and 0.74 ± 0.03 in the control group, while the pCVI values were 0.64 ± 0.04 in the MDD group and 0.71 ± 0.03 in the control group (p < 0.001).The TCA and SCA values were similar between the two groups (p > 0.05 for both).
CONCLUSION: The findings highlight the significance of these current, non-invasive, rapid, and reproducible indices obtained through choroidal imaging for elucidating the etiopathogenesis and diagnosis of MDD,a disorder considered to have a neurodegenerative component.
METHODS: This prospective comparative study was conducted on 50 patients with newly diagnosed MDD and 50 age- and sex-matched healthy participants. All participants underwent an ophthalmological examination, and their demographic characteristics were recorded. Choroidal images obtained from the HD-line optical coherence tomography sections of both groups were analyzed in both the foveal and peripapillary regions.Choroidal thickness measurements were obtained, and choroidal vascular parameters were determined using a specialized free software program.These parameters included the luminal choroidal area (LCA), stromal choroidal area (SCA), and total choroidal area (TCA).The ratio of LCA to TCA was defined as CVI.
RESULTS: No statistically significant differences were found between the groups concerning choroidal thickness, optic disc head measurements, or peripapillary retinal nerve fiber layer thickness (p > 0.05 for all).In the MDD group, the sfLCA was 0.11 ± 0.04 mm2 and the pLCA was 0.12 ± 0.03 mm2, whereas in the control group, these measurements were 0.16 ± 0.05 mm2 and 0.16 ± 0.02 mm2, respectively (p = 0.003 and p = 0.005,respectively).The sfCVI values were 0.61 ± 0.03 in the MDD group and 0.74 ± 0.03 in the control group, while the pCVI values were 0.64 ± 0.04 in the MDD group and 0.71 ± 0.03 in the control group (p < 0.001).The TCA and SCA values were similar between the two groups (p > 0.05 for both).
CONCLUSION: The findings highlight the significance of these current, non-invasive, rapid, and reproducible indices obtained through choroidal imaging for elucidating the etiopathogenesis and diagnosis of MDD,a disorder considered to have a neurodegenerative component.