Case reports in pulmonology · 2026
Resolution of Pulmonary Inflammation and Obstruction Following Repair of Cerebrospinal Fluid Leak: A Case Report and Review of the Literature.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Birmingham Ann O, Staicu Serban A, Schmale Isaac L, Man Li-Xing
Аннотация
OBJECTIVES: Cerebrospinal fluid (CSF) rhinorrhea involves drainage of CSF through the nasal cavity due to disruption of the skull base, and pneumonitis secondary to CSF aspiration is a lesser-known complication reported. We present the case of a patient whose pulmonary symptoms and function improved after surgical CSF leak repair.
METHODS: This is a case report with review of the electronic medical record and literature review.
RESULTS: A 35-year-old female presented with 1 year of refractory right-sided rhinorrhea and recurrent lower respiratory infections. Nasal drainage was positive for beta-2-transferrin. Sinus CT showed a possible leakage site at the right lateral lamella of the cribriform plate. Chest CT showed upper lobe predominant ground-glass opacities. Following surgical CSF leak repair, chest CT showed resolution of ground-glass opacities and pulmonary function testing showed an increase in spirometric lung volumes.
CONCLUSIONS: Aspiration pneumonitis from CSF leaks is rarely reported. Studies report resolution of ground-glass opacities on chest CT as well as clinical improvement in symptoms such as cough following surgical leak repair. Proposed mechanisms leading to aspiration pneumonitis include nasopharyngeal bacterial transit; the mechanism of persistent leak may be related to cough-induced increase in intracranial pressure leading to increased CSF flow. In patients with lower airway inflammation and obstruction as well as unexplained aspiration pneumonitis, a high index of suspicion for CSF rhinorrhea is warranted.
METHODS: This is a case report with review of the electronic medical record and literature review.
RESULTS: A 35-year-old female presented with 1 year of refractory right-sided rhinorrhea and recurrent lower respiratory infections. Nasal drainage was positive for beta-2-transferrin. Sinus CT showed a possible leakage site at the right lateral lamella of the cribriform plate. Chest CT showed upper lobe predominant ground-glass opacities. Following surgical CSF leak repair, chest CT showed resolution of ground-glass opacities and pulmonary function testing showed an increase in spirometric lung volumes.
CONCLUSIONS: Aspiration pneumonitis from CSF leaks is rarely reported. Studies report resolution of ground-glass opacities on chest CT as well as clinical improvement in symptoms such as cough following surgical leak repair. Proposed mechanisms leading to aspiration pneumonitis include nasopharyngeal bacterial transit; the mechanism of persistent leak may be related to cough-induced increase in intracranial pressure leading to increased CSF flow. In patients with lower airway inflammation and obstruction as well as unexplained aspiration pneumonitis, a high index of suspicion for CSF rhinorrhea is warranted.