Levocetirizine in the treatment of allergic diseases.

BACKGROUND

Levocetirizine, the R-enantiomer of cetirizine dihydrochloride, is a new molecule with a potent and selective antihistamine activity.

OBJECTIVE

To investigate the evidence that levocetirizine is an effective therapy for allergic disease.

METHODS

Evaluation of published articles in English, or having an English abstract.

RESULTS

Clinical trials indicate that levocetirizine is safe and effective for the treatment of allergic rhinitis and chronic idiopathic urticaria. The compound shows a rapid onset of action, high bioavailability and affinity for the H1 receptor. Moreover, this molecule demonstrates many anti-inflammatory effects that enhance the clinical therapeutic benefit not only in short-term but also in long-term treatments, as reported in recent trials utilizing levocetirizine for several months.

CONCLUSION

Levocetirizine confirms its safe effective activity for treatment of allergic disease in both adults and children.