[Factors associated with thrombosis of the left atrial appendage in patients with chronic atrial fibrillation].

This study was designed to elucidate hemostatic and genetic characteristics associated with thrombosis of the left atrial appendage (LAA) in patients with chronic atrial fibrillation (AF). It included 91 patients (mean age 62 ± 7.6 years) with coronary heart disease (CHD) and chronic AF. Group I was comprised of 63 patients without LAA thrombosis, group 2 contained 28 patients with LAA thrombosis diagnosed by transesophageal echocardiography. The following parameters were measured: soluble fibrin monomeric complex, fibrinogen, antithrombin, thrombin-activated fibrinolysis inhibitor levels and polymorphism of YP29, VKORC1, PAI-1 genes. Multifactor regression analysis revealed significant association of LAA thrombosis with thrombin-activated fibrinolysis inhibitor level in excess of 245%, the presence of CC genotype of the VKORC1 gene and 4G allele of the PAl-1 gene.