Annals of surgical oncology · 2025
Global, Regional, and National Sex Disparities in the Burden of Malignant Neoplasms of Bone and Articular Cartilage: a Systematic Analysis and Projections to 2050.
СтатьяНазвание и аннотация: Перевод в очереди
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Wang Hao, Guan Mingjing, Li Luling, Zhao Zhijie, Wu Jie, Liu Daohong, Chen Mingxue
Аннотация
BACKGROUND: Primary malignant neoplasms of bone and articular cartilage disproportionately affect younger populations, causing premature mortality and long-term disability. Despite recognized sex-based disparities, global analyses of sociodemographic influences and future projections remain limited.
METHODS: Using the Global Burden of Disease 2021 data from global, regional, and national levels across 204 countries or territories, we analyzed sex-, age-, and region-stratified incidence, mortality, and disability-adjusted life years (DALYs). In addition, we evaluated temporal trends (1990-2021), socioeconomic disparities, and projected burden to 2050.
RESULTS: Between 1990 and 2021, global age-standardized incidence rate increased 14.28%; males experienced an 18.3% increase compared with 7.68% in females. Age-standardized mortality rate stabilized globally but diverged by sex (males: +2.09%; females: -3.91%). Age-standardized DALYs rate increased marginally overall (0.1%), driven by rising male (+3.95%) and declining female (-5.95%) burdens. Lower socioeconomic regions (e.g., eastern sub-Saharan Africa, southeast Asia) faced disproportionately high burdens, contrasting with high-income regions. By 2050, the ASIR for male is projected to increase 20.44%, whereas female may decline (-12.99%), with low Sociodemographic Index countries bearing escalating burdens.
CONCLUSIONS: Persistent gender disparities highlight higher incidence, mortality, and DALYs among males, consistent across regions and most age groups. The shifting burden toward lower-resource settings underscores systemic inequities in healthcare access.
METHODS: Using the Global Burden of Disease 2021 data from global, regional, and national levels across 204 countries or territories, we analyzed sex-, age-, and region-stratified incidence, mortality, and disability-adjusted life years (DALYs). In addition, we evaluated temporal trends (1990-2021), socioeconomic disparities, and projected burden to 2050.
RESULTS: Between 1990 and 2021, global age-standardized incidence rate increased 14.28%; males experienced an 18.3% increase compared with 7.68% in females. Age-standardized mortality rate stabilized globally but diverged by sex (males: +2.09%; females: -3.91%). Age-standardized DALYs rate increased marginally overall (0.1%), driven by rising male (+3.95%) and declining female (-5.95%) burdens. Lower socioeconomic regions (e.g., eastern sub-Saharan Africa, southeast Asia) faced disproportionately high burdens, contrasting with high-income regions. By 2050, the ASIR for male is projected to increase 20.44%, whereas female may decline (-12.99%), with low Sociodemographic Index countries bearing escalating burdens.
CONCLUSIONS: Persistent gender disparities highlight higher incidence, mortality, and DALYs among males, consistent across regions and most age groups. The shifting burden toward lower-resource settings underscores systemic inequities in healthcare access.