Future oncology (London, England) · 2025
Post-surgery recurrence predictors for stage I-II endometrial carcinoma: a retrospective observational study.
СтатьяНаблюдательное исследованиеНазвание и аннотация: Перевод в очереди
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Li Yushan, Wang Hongli, Zhao Shuyun
Аннотация
PURPOSE: A retrospective observational study was conducted to investigate the predictors for recurrence of stage I-II endometrial cancer after surgical treatment.
METHODS: 130 stage I-II endometrioid carcinoma patients receiving laparoscopic surgery in Jincheng People's Hospital from January 2019 to January 2022 were retrospectively selected and diagnosed via HE assay. Their clinic and histology characteristics were collected. Kaplan-Meier survival analysis was to analyze the effect of chemotherapy and radiotherapy on the survival rate of the recurrent patients. Multivariate analysis was to explore the factors affecting postoperative recurrence.
RESULTS: Diagnosis was confirmed by diagnostic curettage in 129 cases. In 130 patients, the invading of superficial myometrium and deep myometrium was more obvious. After chemotherapy and radiotherapy treatment, the 5-year survival rate was 78.46%, and it was different among two therapies; (p = 0.006). Pathological type, disease stage, histological grade and myometrial invasion were the risk factors for recurrence. No significant difference in endometrioid adenocarcinoma proportion between 50 years old and ≤50 years old; (p > 0.05).
CONCLUSION: The Stage I-II endometrial cancer recurrence after laparoscopic surgery can be judged by pathological type, disease stage, histological grade and myometrial invasion, providing theoretical basis for disease treatment to reduce the recurrence and improve the prognosis.
METHODS: 130 stage I-II endometrioid carcinoma patients receiving laparoscopic surgery in Jincheng People's Hospital from January 2019 to January 2022 were retrospectively selected and diagnosed via HE assay. Their clinic and histology characteristics were collected. Kaplan-Meier survival analysis was to analyze the effect of chemotherapy and radiotherapy on the survival rate of the recurrent patients. Multivariate analysis was to explore the factors affecting postoperative recurrence.
RESULTS: Diagnosis was confirmed by diagnostic curettage in 129 cases. In 130 patients, the invading of superficial myometrium and deep myometrium was more obvious. After chemotherapy and radiotherapy treatment, the 5-year survival rate was 78.46%, and it was different among two therapies; (p = 0.006). Pathological type, disease stage, histological grade and myometrial invasion were the risk factors for recurrence. No significant difference in endometrioid adenocarcinoma proportion between 50 years old and ≤50 years old; (p > 0.05).
CONCLUSION: The Stage I-II endometrial cancer recurrence after laparoscopic surgery can be judged by pathological type, disease stage, histological grade and myometrial invasion, providing theoretical basis for disease treatment to reduce the recurrence and improve the prognosis.