Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2008
Assessment of the phototoxic potential of cosmetic products.
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Hans Rajendra K, Agrawal Neeraj, Verma Kiran, Misra Rajendra B, Ray Ratan S, Farooq Mohammad
Аннотация
The cosmetics are nontoxic or less toxic in perse but photoactivation may then sensitize and could produce additional phototoxicity. Phototoxicity assessment of ten different lipsticks and eight facial creams was conducted. Results revealed that six lipsticks and five facial creams generated reactive oxygen species (ROS), produced haemolysis and caused lipid peroxidation in human erythrocytes (in vitro) under sunlight exposure. Seven creams and one lipstick were alkaline while one cream and two lipsticks were acidic. The test lipsticks and creams showed absorption in UV/visible range. The study demonstrated synergistic action of cosmetic products and sunlight. Therefore, sunlight exposure should be avoided after the use of photosensitive cosmetics.