Head & neck · 2016
Pattern of lymph node metastasis in hypopharyngeal squamous cell carcinoma and indications for level VI lymph node dissection.
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Chung Eun-Jae, Kim Go-Woon, Cho Bum-Ki, Park Hae Sang, Rho Young-Soo
Аннотация
BACKGROUND: The purpose of this study was to determine the incidence, risk factors, and prognostic significance of level VI lymph node metastases from hypopharyngeal squamous cell carcinoma (SCC).
METHODS: A retrospective review of 68 previously untreated patients with hypopharyngeal SCC who underwent level VI node dissection was performed.
RESULTS: Level VI lymph node metastases occurred in 27.9% of patients. The occult metastasis rate of level VI node was 14.3%. Patients with level VI metastasis had significantly lower disease-specific (55.1% vs 26.3%) and overall survival rates (73.5% vs 31.6%). Level VI lymph node metastasis was significantly correlated with regional recurrence (83.7% vs 63.2%) and distant metastasis (67.3% vs 47.4%). Multivariate analysis revealed that pyriform sinus apex invasion (odds ratio [OR] = 5.106) was an independent factor for level VI nodal metastasis.
CONCLUSION: Level VI lymph nodes should be removed in patients with pyriform sinus apex invasion, especially in those with advanced nodal disease. © 2016 Wiley Periodicals, Inc. Head Neck 38: E1969-E1973, 2016.
METHODS: A retrospective review of 68 previously untreated patients with hypopharyngeal SCC who underwent level VI node dissection was performed.
RESULTS: Level VI lymph node metastases occurred in 27.9% of patients. The occult metastasis rate of level VI node was 14.3%. Patients with level VI metastasis had significantly lower disease-specific (55.1% vs 26.3%) and overall survival rates (73.5% vs 31.6%). Level VI lymph node metastasis was significantly correlated with regional recurrence (83.7% vs 63.2%) and distant metastasis (67.3% vs 47.4%). Multivariate analysis revealed that pyriform sinus apex invasion (odds ratio [OR] = 5.106) was an independent factor for level VI nodal metastasis.
CONCLUSION: Level VI lymph nodes should be removed in patients with pyriform sinus apex invasion, especially in those with advanced nodal disease. © 2016 Wiley Periodicals, Inc. Head Neck 38: E1969-E1973, 2016.