Ocular immunology and inflammation · 2021
Two Cases of Extremely High-IL-6 Pan-uveitis with Subretinal Exudation and Cell Migration.
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Tagami Mizuki, Misawa Norihiko, Sakai Atsushi, Honda Shigeru
Аннотация
PURPOSE: To describe two cases of extremely high-IL-6 pan-uveitis with subretinal exudation and cell migration.
METHODS: Pre-operative and postoperative images and IL-6 values in vitreous samples of two pan-uveitis cases were analyzed.
RESULTS: Case 1 was a 76-year-old man with blurry vision in his right eye. Fundus examination and optical coherence tomography showed vitreous opacification with vitreous cells and the presence of a white-yellowish retinal exudate with peripheral choroidal detachment all around. The IL-6 value was 16,600 pg/ml. Case 2 was a 63-year-old man with blurry vision in his right eye. On fundus examination, there was severe vitreous opacification in his right eye. The IL-6 value was 26,600 pg/ml. Importantly, there was good responsiveness to steroids and the TNF inhibitor.
CONCLUSION: Unclassified intraocular inflammation might include a new category of disease with unilateral pan-uveitis with good response to steroid therapy and extremely high vitreous IL-6 values.
METHODS: Pre-operative and postoperative images and IL-6 values in vitreous samples of two pan-uveitis cases were analyzed.
RESULTS: Case 1 was a 76-year-old man with blurry vision in his right eye. Fundus examination and optical coherence tomography showed vitreous opacification with vitreous cells and the presence of a white-yellowish retinal exudate with peripheral choroidal detachment all around. The IL-6 value was 16,600 pg/ml. Case 2 was a 63-year-old man with blurry vision in his right eye. On fundus examination, there was severe vitreous opacification in his right eye. The IL-6 value was 26,600 pg/ml. Importantly, there was good responsiveness to steroids and the TNF inhibitor.
CONCLUSION: Unclassified intraocular inflammation might include a new category of disease with unilateral pan-uveitis with good response to steroid therapy and extremely high vitreous IL-6 values.