Zhonghua yi xue za zhi · 1998
[The relationship between Helicobacter pylori and expression of c-met oncogene in gastric precancerous lesions].
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Guo F, Hu F, Jia B
Аннотация
OBJECTIVES: To determine whether there is a relationship between the presence of H. pylori and alteration of c-met oncogene and to estimate the role of H. pylori in the development of gastric carcinoma.
METHODS: 110 patients with histopathologically proven chronic gastritis were studied. We demonstrated expression and overexpression rates of c-met oncogene by using immunohistochemical staining.
RESULTS: For chronic superficial gastritis, chronic atrophic gastritis, intestinal mataplasia and dysplasia, the expression rates were 22.2%, 44.1%, 67.5% and 61.9%. The overexpression rates were 5.5%, 26.4%, 37.8% and 38.1% respectively. The positive rates of c-met oncogene protein were high among patients infected with H. pylori than those with no H. pylori infection (63% vs 32%). In the precancerous lesions of cellular atrophy, intestinal mataplasia and dysplasia, the expression rates of H. pylori positive patients were higher (68.9%) than those of H. pylori negative patients (30.5%) (P < 0.05).
CONCLUSIONS: H. pylori is involved in the expression of c-met oncogene.
METHODS: 110 patients with histopathologically proven chronic gastritis were studied. We demonstrated expression and overexpression rates of c-met oncogene by using immunohistochemical staining.
RESULTS: For chronic superficial gastritis, chronic atrophic gastritis, intestinal mataplasia and dysplasia, the expression rates were 22.2%, 44.1%, 67.5% and 61.9%. The overexpression rates were 5.5%, 26.4%, 37.8% and 38.1% respectively. The positive rates of c-met oncogene protein were high among patients infected with H. pylori than those with no H. pylori infection (63% vs 32%). In the precancerous lesions of cellular atrophy, intestinal mataplasia and dysplasia, the expression rates of H. pylori positive patients were higher (68.9%) than those of H. pylori negative patients (30.5%) (P < 0.05).
CONCLUSIONS: H. pylori is involved in the expression of c-met oncogene.