Cortical gray-white matter contrast alterations precede amyloid-β positivity and macrostructural changes in older adults without dementia.
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Pieperhoff Leonard, Lorenzini Luigi, Almeida Francisco, Tranfa Mario, Bollack Ariane, Arunachalam Prithvi, Masserini Federico, Wolz Robin, Grootoonk Sylke, Ritchie Craig, Boada Mercè, Marquié Marta, Vijverberg Jort, Vandenberghe Rik, Hanseeuw Bernard J, Martinez-Lage Pablo, Payoux Pierre, Visser Pieter Jelle, Schöll Michael, Frisoni Giovanni B, Pardini Matteo, Roccataglia Luca, Stephens Andrew W, Buckley Chris, Farrar Gill, Jessen Frank, Gispert Juan Domingo, Salvadó Gemma, Luckett Emma S, Mutsaerts Henk-Jan Mm, Wink Alle Meije, Collij Lyduine E, Barkhof Frederik, Oliveira Tiago Gil, AMYPAD consortium
Аннотация
METHODS: We analyzed cross-sectional MRI and amyloid-β (Aβ) positron emission tomography (PET) data from 1323 non-demented AMYPAD participants. Cortical volume, thickness, gray-white matter contrast (GWC), and mean diffusivity (MD) were related to global Aβ burden and estimated time to Aβ-positivity using regression, correlation, and change-point analyses.
RESULTS: Microstructural measures showed stronger age associations than macrostructural measures, whereas all measures were unaffected by apolipoprotein E (APOE) -ε4 carriership. GWC and MD showed minimal overlap with volume and thickness. Higher Aβ burden was most strongly associated with reduced GWC and cortical thinning. Change-point analyses showed GWC alterations preceded Aβ-positivity by several years.
DISCUSSION: Cortical microstructural MRI, particularly GWC, changes earlier than atrophy and may serve as an early in vivo marker of AD pathology.