[Chinese expert consensus on the clinical application of wake-promoting agents].

Wake-promoting agents mainly excite the cerebral cortex and promote wakefulness. They are clinically used to treat excessive daytime sleepiness (EDS) caused by narcolepsy and other diseases, or to maintain alertness during special tasks. In recent years, a variety of wake-promoting agents have been approved for the treatment of EDS related to narcolepsy, obstructive sleep apnea and other diseases at home and abroad. However, a dedicated expert consensus on the clinical application of wake-promoting agents remains lacking. To facilitate the rational and standardized clinical application of wake-promoting agents in China, the Sleep Disorders Committee of the Chinese Sleep Research Society convened a multidisciplinary panel of domestic experts. This assembly developed this consensus based on the latest clinical evidence sourced from both domestic and international research, as well as relevant guidelines and their collective clinical expertise. The consensus comprehensively reviews the mechanisms of action, approved indications, clinical studies, dosages, and adverse reactions of various wake-promoting agents. It also provides recommendations on drug selection, titration, and the use of wake-promoting agents in special populations for excessive daytime sleepiness caused by various etiologies. It has strong clinical guidance and clinical application value.