Comparative analysis of Boria's and Suidan's predictive models for complete cytoreduction in advanced ovarian cancer using 18F-FDG PET/CT.

OBJECTIVE

To validate the authors' previously described score (Boria's predictive score) for predicting complete cytoreduction at primary debulking surgery using 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT), combined with clinical variables, and to compare this score with the most commonly used score in the literature (Suidańs predictive score).

METHODS

A multicentre, observational, retrospective study was undertaken to evaluate patients who underwent primary cytoreductive surgery for advanced ovarian cancer at three Spanish centres between January 2017 and January 2022. Inclusion criteria were: histological confirmation of invasive epithelial ovarian carcinoma; preoperative International Federation of Gynecology and Obstetrics stage III or IV; upfront cytoreductive surgery; and 18F-FDG PET/CT performed 1 month prior to surgery. All variables included in the two predictive scores were collected, and the scores were calculated. The area under the curve (AUC) of the receiver operating characteristic curve was calculated for both predictive scores and compared.

RESULTS

In total, 78 patients who had undergone primary debulking surgery and 18F-FDG PET/CT were included. The complete resection rate was 88.4 % (69 patients). Boria`s predictive score had an AUC of 0.738, and Suidańs predictive score had an AUC of 0.79. For Suidan's score, patients with a total score of 0-2 had a complete resection rate of 96.4 % (27/28 patients). The rate decreased to 90.9 % (30/33) and 76.9 % (10/13) in patients with scores of 3-5 and 6-8, respectively. Patients with a score ≥9 had the worst complete resection rate (50 %; 2/4 patients). For Boria`s score, patients with a score of 0-4 (favourable group) had a complete resection rate of 91.5 % (65/71), and patients with a score of 5-16 (unfavourable group) had a complete resection rate of 57.1 % (4/7).

CONCLUSION

With only four variables, Boria`s predictive score showed comparable accuracy to Suidańs score for predicting complete resection at primary debulking surgery.