Journal of fungi (Basel, Switzerland) · 2023
Diagnosis of Aspergillosis in Horses.
СтатьяНазвание и аннотация: Перевод в очереди
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Dobiáš Radim, Jahn Petr, Tóthová Katarina, Dobešová Olga, Višňovská Denisa, Patil Rutuja, Škríba Anton, Jaworská Pavla, Škorič Miša, Podojil Libor, Kantorová Michaela, Mrázek Jakub, Krejčí Eva, Stevens David A, Havlíček Vladimír
Аннотация
Invasive pulmonary aspergillosis (IPA) may be a rare cause of granulomatous pneumonia in horses. The mortality of IPA is almost 100%; direct diagnostic tools in horses are needed. Bronchoalveolar lavage fluid (BALF) and serum samples were collected from 18 horses, including individuals suffering from IPA (n = 1), equine asthma (EA, n = 12), and 5 healthy controls. Serum samples were collected from another 6 healthy controls. Samples of BALF (n = 18) were analyzed for Aspergillus spp. DNA, fungal galactomannan (GM), ferricrocin (Fc), triacetylfusarinin C (TafC), and gliotoxin (Gtx). Analysis of 24 serum samples for (1,3)-β-D-glucan (BDG) and GM was performed. Median serum BDG levels were 131 pg/mL in controls and 1142 pg/mL in IPA. Similar trends were observed in BALF samples for GM (Area under the Curve (AUC) = 0.941) and DNA (AUC = 0.941). The fungal secondary metabolite Gtx was detected in IPA BALF and lung tissue samples (86 ng/mL and 2.17 ng/mg, AUC = 1).