Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2025
Impact of Vitamin D and Calcium on Falls and Fractures in Older Adults.
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Dawson-Hughes Bess
Аннотация
OBJECTIVE: The objective of this review is to explore the evidence linking both low and high circulating levels of 25-hydroxyvitamin D [25(OH)D] to risk of falls and/or fractures in older adults. The important role of calcium intake in this context is also described.
METHODS: The quality of evidence, related to participant characteristics, methods of fall and fracture assessments, biomarker assays employed, and other factors are considered.
RESULTS: There is growing evidence that both low intakes of vitamin D and calcium and excess intake of vitamin D have untoward effects of risk of falls and fractures. From available data, the 25(OH)D range of 20 to 40 ng/ml appears to be associated with minimal risk of falls and fractures.
CONCLUSION: Verification of the 25(OH)D range that currently appears to minimize the risk of falls and fractures, 20 to 40 ng/ml, is important, because it will have obvious implications for devising optimal supplementation strategies in large parts of the global population that is dually deficient in calcium and vitamin D.
METHODS: The quality of evidence, related to participant characteristics, methods of fall and fracture assessments, biomarker assays employed, and other factors are considered.
RESULTS: There is growing evidence that both low intakes of vitamin D and calcium and excess intake of vitamin D have untoward effects of risk of falls and fractures. From available data, the 25(OH)D range of 20 to 40 ng/ml appears to be associated with minimal risk of falls and fractures.
CONCLUSION: Verification of the 25(OH)D range that currently appears to minimize the risk of falls and fractures, 20 to 40 ng/ml, is important, because it will have obvious implications for devising optimal supplementation strategies in large parts of the global population that is dually deficient in calcium and vitamin D.