Photodermatology, photoimmunology & photomedicine · 2026
What Are the Histological Changes Corresponding to Clinical Effacement of Atrophic Acne Scars After Fractional Carbon Dioxide Laser Intervention-A Prospective Interventional Study in Skin of Color.
СтатьяКлиническое исследованиеНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Bansal Abhinav, Sardana Kabir, Paliwal Purnima, Khurana Ananta, Sharath Savitha, Paliwal Prisha
Аннотация
BACKGROUND: Pre-defined dose parameters of fractional carbon dioxide (Fr:CO2) laser used for acne scars are not aligned with the histological depth achieved by the laser, which predicts scar improvement.
OBJECTIVES: To evaluate the baseline histological depth and architecture of different acne scars and compare the histological changes and clinical improvement after Fr:CO2 laser.
METHODS: We conducted a prospective study of atrophic acne scars-ice-pick, boxcar, or rolling. The patients were treated with three sessions of Fr:CO2 laser with pre-determined dosimetry at 3-month intervals. Clinical evaluation was done at every visit using Echelle d'Evaluation clinique des Cicatrices d'acné (ECCA) scoring and individual atrophic acne scars count. Punch biopsy of predominant scars was taken pre- and 1-month post-treatment. The vertical depth of the scars was measured and histological changes in collagen and elastin were noted.
RESULTS: Forty-three patients with atrophic acne scars were included (27 boxcar, 9 ice-pick, and 7 rolling). Median histological depth of ice-pick, rolling and boxcar scars in pre-laser biopsies was 1606, 1546 and 1172 μm respectively, which significantly reduced to 1024 (p = 0.008), 858 (p = 0.018) and 746.5 μm (p < 0.0001) after the final laser session. Significant correlations were noted between acne scar reduction efficiency (ASRE%) and histological parameters at 7 months [ASRE% boxcar, increase in collagen grading (p < 0.05); ASRE% rolling, increased scar vascularization (p = 0.03) and ASRE% ice-pick, increased surrounding dermal elastin (p ≤ 0.05)].
CONCLUSION: Fr:CO2 laser intervention should be guided by scar-specific depth assessment, enabling optimal dosing and correlating this with histological changes would determine clinical improvement in acne scars.
OBJECTIVES: To evaluate the baseline histological depth and architecture of different acne scars and compare the histological changes and clinical improvement after Fr:CO2 laser.
METHODS: We conducted a prospective study of atrophic acne scars-ice-pick, boxcar, or rolling. The patients were treated with three sessions of Fr:CO2 laser with pre-determined dosimetry at 3-month intervals. Clinical evaluation was done at every visit using Echelle d'Evaluation clinique des Cicatrices d'acné (ECCA) scoring and individual atrophic acne scars count. Punch biopsy of predominant scars was taken pre- and 1-month post-treatment. The vertical depth of the scars was measured and histological changes in collagen and elastin were noted.
RESULTS: Forty-three patients with atrophic acne scars were included (27 boxcar, 9 ice-pick, and 7 rolling). Median histological depth of ice-pick, rolling and boxcar scars in pre-laser biopsies was 1606, 1546 and 1172 μm respectively, which significantly reduced to 1024 (p = 0.008), 858 (p = 0.018) and 746.5 μm (p < 0.0001) after the final laser session. Significant correlations were noted between acne scar reduction efficiency (ASRE%) and histological parameters at 7 months [ASRE% boxcar, increase in collagen grading (p < 0.05); ASRE% rolling, increased scar vascularization (p = 0.03) and ASRE% ice-pick, increased surrounding dermal elastin (p ≤ 0.05)].
CONCLUSION: Fr:CO2 laser intervention should be guided by scar-specific depth assessment, enabling optimal dosing and correlating this with histological changes would determine clinical improvement in acne scars.