Soudni lekarstvi · 2015
Traumatic asphyxia: An autopsy case.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Türkmen Nursel, Eren Bülent, Erkol Zerrin
Аннотация
AIM OF THE STUDY: Alcohol is one of the leading causes of liver hepatitis and liver cirrhosis. Both medical conditions are defined by a combination of specific symptoms whose interaction allows for a diagnosis with reasonable precision. This study aimed to differentiate between acute alcoholic hepatitis and alcoholic cirrhosis at the molecular level.
MATERIAL AND METHODS: This report analyzed changes in levels of vitamin D3, tumor necrosis factor α (TNF-α), interleukin (IL)-1β, IL-6, IL-8, IL-12, and adiponectin determined using a chemiluminescent microparticle immunoassay and Luminex xMap technology. The study population consisted of 42 male patients with acute alcoholic hepatitis and 50 male patients with alcoholic cirrhosis.
RESULTS: The result revealed a statistically significant difference in TNF-α, IL-8, and IL-12 between acute alcoholic hepatitis and alcoholic cirrhosis. It also revealed distinct correlation patterns that differentiate acute alcoholic hepatitis and alcoholic cirrhosis. A network of significant cross-correlations between the cytokines studied defines alcoholic cirrhosis.
CONCLUSIONS: This report revealed that the studied medical conditions can be differentiated by specific levels of cytokines and by cross-correlation between cytokines.
MATERIAL AND METHODS: This report analyzed changes in levels of vitamin D3, tumor necrosis factor α (TNF-α), interleukin (IL)-1β, IL-6, IL-8, IL-12, and adiponectin determined using a chemiluminescent microparticle immunoassay and Luminex xMap technology. The study population consisted of 42 male patients with acute alcoholic hepatitis and 50 male patients with alcoholic cirrhosis.
RESULTS: The result revealed a statistically significant difference in TNF-α, IL-8, and IL-12 between acute alcoholic hepatitis and alcoholic cirrhosis. It also revealed distinct correlation patterns that differentiate acute alcoholic hepatitis and alcoholic cirrhosis. A network of significant cross-correlations between the cytokines studied defines alcoholic cirrhosis.
CONCLUSIONS: This report revealed that the studied medical conditions can be differentiated by specific levels of cytokines and by cross-correlation between cytokines.