Journal of ethnopharmacology · 2025
Chemical profile and in-vivo antiulcer activity of Aiphanes eggersii Burret aerial Parts: Involvement of Nrf2/HO-1 activation and NF-κB suppression.
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El-Sayed Elsayed K, Elsayed Heba E, Khattab Mohamed A, Ahmed Asmaa A, Lai Kuei-Hung, Mady Mohamed S, Moharram Fatma A
Аннотация
ETHNOPHARMACOLOGICAL RELEVANCE: Gastric ulcer (GU) is a significant public health challenge that impacts millions globally. Palm tree species (family Arecaceae) have been traditionally adopted for inflammatory and gastrointestinal conditions, among which Aiphanes eggersii Burret remains under exploration.
AIM OF THE STUDY: For the first time, the phenolic profile of defatted aqueous ethanol extract (DAEE) of the palm tree Aiphanes eggersii Burret was carried out, in addition to the anti-ulcer potential of DAEE in an ethanol-induced gastric ulcer (GU) model in rats was assessed.
MATERIALS AND METHODS: The chemical composition was determined using HPLC/MS, chromatographic, and spectroscopic techniques. Rats were pretreated with DAEE (200, 400, and 800 mg/kg) or sucralfate (100 mg/kg) for 14 days before the induction of GU with a single dose of ethanol (5 mL/kg). Gastric tissues were evaluated macroscopically, biochemically, and histologically.
RESULTS: Seven phenolics were isolated, viz, vicenin II (1), rutin (2), quercitrin (3), kaempferin (4), cirsimaritin (5), quercetin (6), and caffeic acid (7). In addition, fifty-one metabolites belonging to various classes were tentatively identified using HPLC/MS. The DAEE significantly declined the ulcer index and improved the gastric protection dose independently. It enhanced the antioxidant effect via decreasing MDA and increasing GSH, SOD, and CAT. It suppressed pro-inflammatory cytokines, including TNF-α, IL-1β, and IL-6, as well as the NF-κB/p65 pathway. Moreover, it upregulated HO-1/Nrf2 signaling, restored PGE2 levels, and decreased the levels of COX-1 and COX-2. Histological findings confirmed mucosal protection and healing.
CONCLUSION: The phenolic-rich extract of A. eggersii Burret exhibits potent gastroprotective activity, supporting its potential as a natural therapeutic for GU management, while clinical investigation is needed.
AIM OF THE STUDY: For the first time, the phenolic profile of defatted aqueous ethanol extract (DAEE) of the palm tree Aiphanes eggersii Burret was carried out, in addition to the anti-ulcer potential of DAEE in an ethanol-induced gastric ulcer (GU) model in rats was assessed.
MATERIALS AND METHODS: The chemical composition was determined using HPLC/MS, chromatographic, and spectroscopic techniques. Rats were pretreated with DAEE (200, 400, and 800 mg/kg) or sucralfate (100 mg/kg) for 14 days before the induction of GU with a single dose of ethanol (5 mL/kg). Gastric tissues were evaluated macroscopically, biochemically, and histologically.
RESULTS: Seven phenolics were isolated, viz, vicenin II (1), rutin (2), quercitrin (3), kaempferin (4), cirsimaritin (5), quercetin (6), and caffeic acid (7). In addition, fifty-one metabolites belonging to various classes were tentatively identified using HPLC/MS. The DAEE significantly declined the ulcer index and improved the gastric protection dose independently. It enhanced the antioxidant effect via decreasing MDA and increasing GSH, SOD, and CAT. It suppressed pro-inflammatory cytokines, including TNF-α, IL-1β, and IL-6, as well as the NF-κB/p65 pathway. Moreover, it upregulated HO-1/Nrf2 signaling, restored PGE2 levels, and decreased the levels of COX-1 and COX-2. Histological findings confirmed mucosal protection and healing.
CONCLUSION: The phenolic-rich extract of A. eggersii Burret exhibits potent gastroprotective activity, supporting its potential as a natural therapeutic for GU management, while clinical investigation is needed.