Japanese journal of radiology · 2025
Correlation between collateral compensation of the posterior cerebral artery on 5 T magnetic resonance imaging and clinical classifications in patients with Moyamoya angiopathy.
СтатьяНазвание и аннотация: Перевод в очереди
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Han Guangsong, Fan Xiaoyuan, Hong Yuehui, Yao Ming, Zhou Lixin, Zhu Yicheng, Feng Feng, Ni Jun
Аннотация
PURPOSE: Various clinical classifications of Moyamoya angiopathy (MMA) have different characteristics of collateral compensation. Advancements in 5 T MRI have made it possible to non-invasively assess vascular collateralization using 4-dimensional MR angiography (4DMRA). The objective of this study is to analyze collateral compensation in MMA patients using 4DMRA and determine variations among different clinical classifications.
MATERIALS AND METHODS: Collateral compensation of posterior cerebral artery (PCA) to anterior circulation was evaluated using 4DMRA at 5 T MRI. After adjusting for confounding factors, multivariate analyses were conducted to compare the distribution of PCA collateral compensation among patients with different clinical classifications of MMA.
RESULTS: 85 MMA patients were enrolled in the study. Among the 158 hemispheres evaluated, 100 were asymptomatic, 7 were hemorrhagic, 50 were ischemic, and 1 had a combination of hemorrhagic and ischemic stroke. Multivariate logistic regression analysis revealed a statistically significant difference in total PCA collateral compensation scores between asymptomatic and ischemic hemispheres (P < 0.001, 95% CI [0.614, 0.839]). Subgroup analysis revealed a clear distinction between asymptomatic hemispheres and ischemic hemispheres (P = 0.001, 95% CI [0.193, 0.677]) in terms of PCA compensation to middle cerebral artery through the parieto-occipital branch. However, no notable differences were observed in other compensation pathways.
CONCLUSION: The collateral compensation of PCA to the anterior circulation in MMA patients, assessed by 4DMRA at 5 T MRI, is significantly associated with ischemic MMA. The parieto-occipital branch may be the most important compensatory pathway. 4DMRA can potentially serve as a valuable tool for evaluating the risk of ischemic stroke in patients with MMA.
MATERIALS AND METHODS: Collateral compensation of posterior cerebral artery (PCA) to anterior circulation was evaluated using 4DMRA at 5 T MRI. After adjusting for confounding factors, multivariate analyses were conducted to compare the distribution of PCA collateral compensation among patients with different clinical classifications of MMA.
RESULTS: 85 MMA patients were enrolled in the study. Among the 158 hemispheres evaluated, 100 were asymptomatic, 7 were hemorrhagic, 50 were ischemic, and 1 had a combination of hemorrhagic and ischemic stroke. Multivariate logistic regression analysis revealed a statistically significant difference in total PCA collateral compensation scores between asymptomatic and ischemic hemispheres (P < 0.001, 95% CI [0.614, 0.839]). Subgroup analysis revealed a clear distinction between asymptomatic hemispheres and ischemic hemispheres (P = 0.001, 95% CI [0.193, 0.677]) in terms of PCA compensation to middle cerebral artery through the parieto-occipital branch. However, no notable differences were observed in other compensation pathways.
CONCLUSION: The collateral compensation of PCA to the anterior circulation in MMA patients, assessed by 4DMRA at 5 T MRI, is significantly associated with ischemic MMA. The parieto-occipital branch may be the most important compensatory pathway. 4DMRA can potentially serve as a valuable tool for evaluating the risk of ischemic stroke in patients with MMA.