Laryngeal non-Hodgkin lymphoma presenting as throat foreign body sensation: A case report.

RATIONALE: Laryngeal lymphoma is an extremely rare malignancy, representing <1% of all laryngeal tumors. Diffuse large B-cell lymphoma (DLBCL) is the most common histologic subtype. Due to its rarity and nonspecific symptoms, early diagnosis and timely treatment are critical.

PATIENT CONCERNS: A 67-year-old male presented with progressive hoarseness and a persistent sensation of a foreign body in the throat that had developed over several weeks.

DIAGNOSES: Laryngoscopy revealed a submucosal mass involving the glottis. Contrast-enhanced computed tomography demonstrated soft tissue infiltration. Surgical excision was performed, and histopathological evaluation confirmed the diagnosis of diffuse large B-cell lymphoma of the larynx.

INTERVENTIONS: The patient received systemic chemotherapy tailored to the staging and anatomical location of the lymphoma, following current DLBCL treatment guidelines.

OUTCOMES: The patient experienced significant symptom relief after chemotherapy, with resolution of hoarseness and foreign body sensation. No recurrence was observed during the 2-month follow-up period.

LESSONS: This case highlights the importance of considering lymphoma in the differential diagnosis of persistent hoarseness and throat discomfort. Early biopsy and multidisciplinary intervention are essential to achieve favorable outcomes in patients with rare laryngeal DLBCL.