Case reports in dermatology · 2025
Cutaneous Rosai-Dorfman Disease: A Report of 2 Cases and a Review of Recent Literature (2018-2023).
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Mohaghegh Fatemeh, Saber Mina, Rajabi Parvin, Sohrabi Haniyeh
Аннотация
INTRODUCTION: Rosai-Dorfman disease (RDD) is a rare, benign histiocytic disorder that can present as isolated cutaneous RDD (CRDD), often mimicking other dermatologic conditions and complicating diagnosis.
CASE PRESENTATION: We report two cases of CRDD: one with palms and soles involvement, and another as an exophytic facial mass, initially misdiagnosed and unsuccessfully treated. Dermoscopy revealed distinctive features, including yellow ovoid structures, linear vessels, and cotton-like white globules. Histopathological and immunohistochemical analyses confirmed CRDD with histiocytic infiltration and emperipolesis, key histological markers of CRDD.
CONCLUSION: A review of 53 cases (2018-2023) highlights CRDD's clinical variability, common anatomical sites, and diverse treatment responses, emphasizing the need for individualized management and early recognition for optimal treatment. These findings contribute to a broader understanding of CRDD and support a multidisciplinary approach to optimizing patient care.
CASE PRESENTATION: We report two cases of CRDD: one with palms and soles involvement, and another as an exophytic facial mass, initially misdiagnosed and unsuccessfully treated. Dermoscopy revealed distinctive features, including yellow ovoid structures, linear vessels, and cotton-like white globules. Histopathological and immunohistochemical analyses confirmed CRDD with histiocytic infiltration and emperipolesis, key histological markers of CRDD.
CONCLUSION: A review of 53 cases (2018-2023) highlights CRDD's clinical variability, common anatomical sites, and diverse treatment responses, emphasizing the need for individualized management and early recognition for optimal treatment. These findings contribute to a broader understanding of CRDD and support a multidisciplinary approach to optimizing patient care.