Journal of perinatal medicine · 2025
Serum vitamin D and inflammatory markers in SARS-CoV-2 positive pregnant women.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Mesarič Vita Andreja, Premru Sršen Tanja, Kavšek Gorazd, Verdenik Ivan, Štrukelj Aleksandra, Druškovič Mirjam
Аннотация
OBJECTIVES: The SARS-CoV-2 pandemic was declared by World Health Organisation (WHO) in March 2020, causing health and economic disruptions and millions of deaths. Pregnant women represent a vulnerable group, as COVID-19 during pregnancy increases the risk of preterm birth, preeclampsia, and severe maternal illness. Nutritional status, such as vitamin D deficiency, may influence these outcomes, yet data on its status in the cohort of SARS-CoV-2 positive pregnant women as well as its association with inflammatory and angiogenic markers is scarce. The aim of this study was to evaluate the levels of vitamin D in the cohort of SARS-CoV-2 positive pregnant women and its association with inflammatory and angiogenic markers.
METHODS: Prospective cohort study at Ljubljana Maternity Hospital (Oct 1, 2020-Mar 30, 2021) enrolled singleton pregnancies with PCR-confirmed SARS-CoV-2 within the last 14 days, delivering at our institution.
RESULTS: Among 235 SARS-CoV-2-positive pregnant women 62.1 % had adequate and 21.3 % insufficient level of vitamin D and 13.6 % were vitamin D deficient. Statistical analysis revealed no significant correlations between 25-OH-vitamin D and C-reactive protein (CRP), procalcitonin (PCT), leukocyte count, soluble fms-like tyrosine kinase-1 (sFlt-1), placental growth factor (PlGF), the sFlt-1/PlGF ratio, or body mass index (BMI).
CONCLUSIONS: Our prospective cohort study revealed that high proportion of pregnant women has inadequate levels of vitamin D. Although maternal insufficiency is linked to adverse outcomes, its association with inflammatory and angiogenic markers remains unclear. Rigorous studies in pregnancy are essential to clarify vitamin D's role in COVID-19 complications in pregnancy.
METHODS: Prospective cohort study at Ljubljana Maternity Hospital (Oct 1, 2020-Mar 30, 2021) enrolled singleton pregnancies with PCR-confirmed SARS-CoV-2 within the last 14 days, delivering at our institution.
RESULTS: Among 235 SARS-CoV-2-positive pregnant women 62.1 % had adequate and 21.3 % insufficient level of vitamin D and 13.6 % were vitamin D deficient. Statistical analysis revealed no significant correlations between 25-OH-vitamin D and C-reactive protein (CRP), procalcitonin (PCT), leukocyte count, soluble fms-like tyrosine kinase-1 (sFlt-1), placental growth factor (PlGF), the sFlt-1/PlGF ratio, or body mass index (BMI).
CONCLUSIONS: Our prospective cohort study revealed that high proportion of pregnant women has inadequate levels of vitamin D. Although maternal insufficiency is linked to adverse outcomes, its association with inflammatory and angiogenic markers remains unclear. Rigorous studies in pregnancy are essential to clarify vitamin D's role in COVID-19 complications in pregnancy.