Anticancer research · 2021
How Much Daily Image-guided Volumetric Modulated Arc Therapy Is Useful for Proctitis Prevention With Respect to Static Intensity Modulated Radiotherapy Supported by Topical Medications Among Localized Prostate Cancer Patients?
СтатьяНазвание и аннотация: Перевод в очереди
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Ferini Gianluca, Tripoli Antonella, Molino Laura, Cacciola Alberto, Lillo Sara, Parisi Silvana, Umina Vincenza, Illari Salvatore Ivan, Marchese Valentina Anna, Cravagno Irene Rita, Borzì Giuseppina Rita, Valenti Vito
Аннотация
BACKGROUND/AIM: To evaluate if topical support therapy during static-intensity modulated radiotherapy (sIMRT) course is able to equal the characteristic minimum risk for radiation proctitis of Image-guided volumetric modulated arc therapy (IG-VMAT) treatment among localized prostate cancer patients.
PATIENTS AND METHODS: Rectal toxicity data of the above patients were retrospectively collected throughout three different clinical periods at our Radiotherapy Deparment: from October 2011 to December 2012, prostate cancer patients were treated with sIMRT and in advance supported by means of daily topical corticosteroids; from January 2013 to November 2016, topical corticosteroids were replaced by daily hyaluronic acid enemas; from December 2016 to May 2018 eligible patients were treated with newly introduced IG-VMAT supported by only on-demand topical corticosteroids.
RESULTS: Among 359 eligible patients, IG-VMAT was proven generally more effective than sIMRT supported by topical medications in terms of proctitis reduction, although without clinical and practical relevance.
CONCLUSION: Topical medications might have a role in radiation proctitis prevention.
PATIENTS AND METHODS: Rectal toxicity data of the above patients were retrospectively collected throughout three different clinical periods at our Radiotherapy Deparment: from October 2011 to December 2012, prostate cancer patients were treated with sIMRT and in advance supported by means of daily topical corticosteroids; from January 2013 to November 2016, topical corticosteroids were replaced by daily hyaluronic acid enemas; from December 2016 to May 2018 eligible patients were treated with newly introduced IG-VMAT supported by only on-demand topical corticosteroids.
RESULTS: Among 359 eligible patients, IG-VMAT was proven generally more effective than sIMRT supported by topical medications in terms of proctitis reduction, although without clinical and practical relevance.
CONCLUSION: Topical medications might have a role in radiation proctitis prevention.
Предметные рубрики MeSH
Administration, TopicalAgedAged, 80 and overAnti-Inflammatory AgentsBeclomethasoneEnemaHumansHyaluronic AcidItalyMaleMiddle AgedOrgan Sparing TreatmentsProctitisProstatic NeoplasmsRadiation Dose HypofractionationRadiation InjuriesRadiotherapy Planning, Computer-AssistedRadiotherapy, Image-GuidedRadiotherapy, Intensity-ModulatedRetrospective Studies