Cureus · 2025
Association of Hypocapnia With Febrile Seizures: A Cross-Sectional Observational Study.
СтатьяНазвание и аннотация: Перевод в очереди
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S Archana, Ravi Karunya, Raju Prasanna, Rangaraj Suresh
Аннотация
BACKGROUND: Febrile seizures are a benign condition with unexplained pathophysiology. Respiratory alkalosis due to increased temperature can cause cerebral alkalosis and seizures.
OBJECTIVES: The objective of this study is to assess the association of hypocapnia and respiratory alkalosis with the time of presentation after febrile seizures.
STUDY DESIGN: This is a cross-sectional observational study.
PARTICIPANTS: A total of 51 children admitted to SRM Medical College Hospital over a period of one year (September 2020-September 2021) were included in the study.
INTERVENTION: Venous blood gas was measured at admission. The presence of hypocapnia and respiratory alkalosis were analyzed along with the time of admission from the onset of seizures.
RESULTS: When comparing temperature values with pH values as a linear regression, there was a positive correlation (r = 0.39, P = 0.005). Children who presented earlier were more likely to have respiratory alkalosis compared to those who presented late (P = 0.000).
CONCLUSIONS: Febrile seizures could be associated with blood pH changes, making way for newer therapeutic approaches and the need for subsequent clinical trials.
OBJECTIVES: The objective of this study is to assess the association of hypocapnia and respiratory alkalosis with the time of presentation after febrile seizures.
STUDY DESIGN: This is a cross-sectional observational study.
PARTICIPANTS: A total of 51 children admitted to SRM Medical College Hospital over a period of one year (September 2020-September 2021) were included in the study.
INTERVENTION: Venous blood gas was measured at admission. The presence of hypocapnia and respiratory alkalosis were analyzed along with the time of admission from the onset of seizures.
RESULTS: When comparing temperature values with pH values as a linear regression, there was a positive correlation (r = 0.39, P = 0.005). Children who presented earlier were more likely to have respiratory alkalosis compared to those who presented late (P = 0.000).
CONCLUSIONS: Febrile seizures could be associated with blood pH changes, making way for newer therapeutic approaches and the need for subsequent clinical trials.