Sex-Related Outcome After Sutureless Aortic Valve Replacement With Perceval Plus: Results From a Global Registry and Meta-Regression.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Santarpino Giuseppe, Lorusso Roberto, Di Mauro Michele, D'Anna Veronica, Prencipe Chiara Maria, Voisine Pierre, Bisleri Gianluigi, Parrino Eugene, Bates Michael, Hughes G Chad, Roselli Eric, Baeza Cristian, Heimansohn David, Bové Thierry, Meuris Bart, Gutermann Herbert, Corbi Pierre, Pollari Francesco, Awad George, Kappert Utz, Mellert Friedrich, Shehada Sharaf-Eldin, Girdauskas Evaldas, Troise Giovanni, Solinas Marco, Minniti Giuseppe, Mazzaro Enzo, Rinaldi Mauro, Pacini Davide, Argano Vincenzo, Torella Michele, Lam Ka Yan, Micovic Slobodan, Siepe Matthias, Baghai Max, Lee Seung Hyun, Choi Jae Woong, Je Hyung Gon, Nobre Angelo
Аннотация
METHODS: Up to September 2024, 535 subjects (261 women) received Perceval Plus at 35 investigational sites from Mitral, Aortic aNd Tricuspid Post-maRket Study in a reAl-world Setting observational prospective registry. Moreover, meta-regression was performed to assess whether sex modifies outcomes.
RESULTS: Men have a larger body size (body surface area: male 2.0 ± 0.2 vs female 1.8 ± 0.2, P < .001), resulting in a larger prosthesis size (size S: male 2.9% vs female 34.9%). Surgery was still significantly faster in women (cross-clamp time: male 63.7 ± 29.4 min vs female 56.8 ± 29.4 min, P = .002), partly because approximately 10% of procedures in male patients were combined, increasing duration. Early outcomes were comparable between sexes (hospital deaths: male 3 [1.1%] vs female 5 [1.9%], P = .49). At follow-up, no significant differences were observed (follow-up deaths: male 9 [3.3%] vs female 5 [1.9%], P = .42). Meta-regression showed no effect of female sex prevalence.
CONCLUSIONS: Our registry and meta-regression analysis did not reveal significant differences in outcomes between men and women. Preoperative characteristics, however, differ between sexes and may influence outcomes and prosthesis choice. Long-term conclusions are limited by the current follow-up duration and will be further explored as data collection progresses.
CLINICAL REGISTRATION NUMBER: NCT05002543, ClinicalTrials.gov (https://clinicaltrials.gov/study/NCT05002543).