Archives of neurology · 2000
Three families with polyneuropathy associated with monoclonal gammopathy.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Manschot S M, Notermans N C, van den Berg L H, Verschuuren J J, Lokhorst H M
Аннотация
OBJECTIVE: To report familial occurrence of polyneuropathy associated with monoclonal gammopathy.
DESIGN: Case reports.
PATIENTS: We describe 6 patients (3 pairs) with a polyneuropathy associated with IgM monoclonal gammopathy. Four of the 6 patients had a demyelinating polyneuropathy on neurophysiological examination. Three patients had elevated antibodies against myelin-associated glycoprotein. No duplication on chromosome 17 or a mutation on chromosome 1 was found in any family.
CONCLUSION: Familial occurrence of polyneuropathy without the presence of hereditary motor and sensory neuropathy type I is a reason to search for the presence of monoclonal gammopathy.
DESIGN: Case reports.
PATIENTS: We describe 6 patients (3 pairs) with a polyneuropathy associated with IgM monoclonal gammopathy. Four of the 6 patients had a demyelinating polyneuropathy on neurophysiological examination. Three patients had elevated antibodies against myelin-associated glycoprotein. No duplication on chromosome 17 or a mutation on chromosome 1 was found in any family.
CONCLUSION: Familial occurrence of polyneuropathy without the presence of hereditary motor and sensory neuropathy type I is a reason to search for the presence of monoclonal gammopathy.