Ultrasound-Guided Percutaneous Cryoneurolysis of Multiple Lower Extremity Nerves for Treatment of Pain From Complex Regional Pain Syndrome: A Case Report.

Complex regional pain syndrome (CRPS) is a multifactorial neuropathic disorder characterized by pain disproportionate to injury. We report a 58-year-old man with CRPS type II of the right lower extremity after traumatic nerve injury, diagnosed via Budapest criteria. After limited response to medical and rehabilitative therapy, ultrasound-guided percutaneous cryoneurolysis was performed on saphenous, deep peroneal, sural, and superficial peroneal nerves. The procedure yielded >80% pain reduction within 1 week and sustained analgesia with improved function at 9 months. This case suggests cryoneurolysis may represent a safe, minimally invasive option for refractory CRPS, warranting further controlled investigation.