Georgian medical news · 2025
COMPARATIVE ASSESSMENT OF THE EFFECT OF SILYMARIN, FENOFIBRATE, BETAINE AND ADEMETIONINE ON THE DEVELOPMENT OF STEATOHEPATITIS IN WISTAR RATS.
СтатьяСравнительное исследованиеНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Zozulya A, Teslevich V, Abkhazava P, Ramazanov I, Tokhtarova S, Streltsova O, Kalsynov G, Chernogoloviy A, Antun D, Gamzaeva S
Аннотация
BACKGROUND: Metabolic dysfunction-associated steatotic liver disease (MASLD), previously termed NAFLD/MAFLD, can be reproduced in rats by a high-fructose diet and leads to hepatic steatosis and liver injury.
AIM: To evaluate and compare the effects of silymarin, fenofibrate, betaine and ademetionine on biochemical and morphological manifestations of high-fructose-induced MASLD in rats.
METHODS: Male Wistar rats (n=20 per group) were fed a high-fructose diet for 5 weeks and treated with one of the four agents. Serum ALT and AST activities and hepatic triglyceride (TG) content were measured. Statistical analysis was performed using one-way ANOVA with Tukey HSD post hoc test; results are presented as mean±SD.
RESULTS: In the fructose control group ALT and AST were 95.2±2.8 and 88.0±2.1 U/L, respectively; hepatic TG concentration was 12.50±0.38 mg/g. Fenofibrate produced the most pronounced effect, lowering hepatic TG by about 60 % (5.02±0.22 mg/g, p<0.001) and reducing ALT and AST by about 40 % (56.8±2.9 U/L and 55.0±2.4 U/L, p<0.001). Silymarin and betaine induced intermediate reductions (all p<0.001), whereas ademetionine markedly lowered transaminases (p<0.001) with only modest effects on hepatic TG (11.94±0.28 mg/g, p<0.001).
CONCLUSION: Fenofibrate was the most effective agent in preventing fructose-induced hepatic steatosis and transaminase elevation, in line with activation of PPAR-α-dependent β-oxidation and inhibition of lipogenesis.
AIM: To evaluate and compare the effects of silymarin, fenofibrate, betaine and ademetionine on biochemical and morphological manifestations of high-fructose-induced MASLD in rats.
METHODS: Male Wistar rats (n=20 per group) were fed a high-fructose diet for 5 weeks and treated with one of the four agents. Serum ALT and AST activities and hepatic triglyceride (TG) content were measured. Statistical analysis was performed using one-way ANOVA with Tukey HSD post hoc test; results are presented as mean±SD.
RESULTS: In the fructose control group ALT and AST were 95.2±2.8 and 88.0±2.1 U/L, respectively; hepatic TG concentration was 12.50±0.38 mg/g. Fenofibrate produced the most pronounced effect, lowering hepatic TG by about 60 % (5.02±0.22 mg/g, p<0.001) and reducing ALT and AST by about 40 % (56.8±2.9 U/L and 55.0±2.4 U/L, p<0.001). Silymarin and betaine induced intermediate reductions (all p<0.001), whereas ademetionine markedly lowered transaminases (p<0.001) with only modest effects on hepatic TG (11.94±0.28 mg/g, p<0.001).
CONCLUSION: Fenofibrate was the most effective agent in preventing fructose-induced hepatic steatosis and transaminase elevation, in line with activation of PPAR-α-dependent β-oxidation and inhibition of lipogenesis.