The Shifting Paradigm of Feline Infectious Peritonitis: New Diagnostics and Therapeutics.

Feline infectious peritonitis (FIP) has long represented one of the most devastating and frustrating diseases in feline medicine. Historically regarded as almost universally fatal, the FIP paradigm has shifted dramatically over the past 5 to 10 years. Safe and effective antiviral therapies, including GS-441524 and related compounds, have transformed FIP into a treatable disease with survival rates previously unimaginable. In parallel, advances in molecular diagnostics and immunocytochemical techniques have improved antemortem diagnostic confidence. This review explores the evolving understanding of FIP pathogenesis, diagnostic testing, and antiviral therapy, emphasizing the rapid pace of change and the implications for contemporary clinical practice.