A Toddler With Iron Deficiency Anemia Secondary to a Yolk Sac Tumor of the Stomach: A Case Report and Literature Review.

Yolk sac tumors, a subset of malignant germ cell tumors originating from gonadal germ cells, most often present as ovarian or testicular tumors in adolescents, sometimes in combination with different types of histology as a mixed malignant germ cell tumor. We describe a female toddler presenting with severe iron deficiency anemia who was found to have a gastric pure yolk sac tumor. Pure yolk sac tumor of the stomach has rarely been reported and is even less frequent in the pediatric population. Our review of the medical literature found 12 case reports of gastric pure yolk sac tumor, of which only 1 was in a child, a 3-year-old male. Our patient underwent subtotal gastrectomy and received adjuvant systemic chemotherapy and is tumor-free at 3 years following surgery. This is the first reported case of a gastric pure yolk sac tumor in a pediatric female, brought to clinical attention due to significant gastrointestinal blood loss.