Long-Term Results after Surgical Treatment of Congenital Penile Curvature Using a Modified Nesbit Technique.

OBJECTIVE

Recurrence patterns and survival outcomes in advanced epithelial ovarian cancer (EOC) treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) remain poorly understood. This post hoc analysis aimed to evaluate patterns of initial recurrence in patients with advanced EOC.

METHODS

This analysis of the KOV-HIPEC1 trial included 142 patients with recurrent EOC divided into HIPEC and non-HIPEC groups. Baseline characteristics, recurrence patterns, and post-recurrence survival (PRS) were analyzed.

RESULTS

Among 142 patients with recurrent disease, recurrence patterns were comparable between the HIPEC and non-HIPEC groups, including rates of peritoneal seeding (80.0% vs. 70.1%, p=0.178), lymphatic involvement (47.7% vs. 49.4%, p=0.844), and parenchymal metastases (10.8% vs. 15.6%). In the BRCA-mutated subgroup, peritoneal seeding was significantly more common in the HIPEC group than in the non-HIPEC group (81.8% vs. 33.3%, p=0.036). PRS did not differ significantly between the HIPEC and control groups (p=0.571). Gastrointestinal events at recurrence were less frequent in the HIPEC group, including intestinal obstruction (1.9% vs. 9.3%), ostomy formation (0% vs. 3.1%), intestinal surgery (0% vs. 5.6%) and nasogastric tube placement (1.9% vs. 7.4%).

CONCLUSION

No significant differences in recurrence pattern or survival outcome were observed between CRS with HIPEC and CRS alone. However, distinct recurrence patterns observed in BRCA-mutated patients suggest potential biological differences that may influence treatment outcomes. A trend toward reduced gastrointestinal morbidity in the HIPEC group, potentially reflecting a more subtle, less invasive recurrence pattern. Further research is warranted to elucidate these observations.