Retinal cases & brief reports · 2026
Misfolded Proteins in the Eye - Vitreous Amyloidosis.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Fasler Katrin, Multone Eléonore, Stahel Marc, Gabathuler Felix, Blaser Frank, Zweifel Sandrine A
Аннотация
PURPOSE: The aim of this study was to describe a case of vitreous amyloidosis as a rare aetiology of vitreous opacities and to show diagnostic value of vitreous biopsy in the diagnostic process as well as show a potiential new non-invasive diagnostic for vitreous amyloidosis.
METHODS: Retrospective case report with presentation of medical record data, clinical imaging, and pathological work-up.
RESULTS: A 82-year-old man underwent diagnostic vitrectomy due to dense vitreous opacities in the right eye. While visual acuity did not improve much due to an underlying advanced fibrotic age related macular degeneration, pathology confirmed amyloid material in the vitreous. The patient was diagnosed with hereditary amyloid transthyretin amyloidosis (ATTRv) and offered a transthyretin stabilising therapy (tafamidis, vindaqel®).
DISCUSSION: While vitreous opacities are a common usually benign phenomenon, it is important to recognise atypical presentation. Diagnostic work-up may include diagnostic vitrectomy, which can aid in diagnosing relevant underlying systemic disease such as ATTRv amyloidosis. While pathologic work-up of vitreous material is the current gold standard, there may be novel non-invasive imaging techniques to aid in diagnosis of vitreous amyloidosis.
METHODS: Retrospective case report with presentation of medical record data, clinical imaging, and pathological work-up.
RESULTS: A 82-year-old man underwent diagnostic vitrectomy due to dense vitreous opacities in the right eye. While visual acuity did not improve much due to an underlying advanced fibrotic age related macular degeneration, pathology confirmed amyloid material in the vitreous. The patient was diagnosed with hereditary amyloid transthyretin amyloidosis (ATTRv) and offered a transthyretin stabilising therapy (tafamidis, vindaqel®).
DISCUSSION: While vitreous opacities are a common usually benign phenomenon, it is important to recognise atypical presentation. Diagnostic work-up may include diagnostic vitrectomy, which can aid in diagnosing relevant underlying systemic disease such as ATTRv amyloidosis. While pathologic work-up of vitreous material is the current gold standard, there may be novel non-invasive imaging techniques to aid in diagnosis of vitreous amyloidosis.